A Phase 2 Randomized Trial Evaluating the Antiviral Activity and Safety of the Direct-Acting Antiviral Bemnifosbuvir in Ambulatory Patients with Mild or Moderate COVID-19 (MOONSONG Study)

A Phase 2 Randomized Trial Evaluating the Antiviral Activity and Safety of the Direct-Acting Antiviral Bemnifosbuvir in Ambulatory Patients with Mild or Moderate COVID-19 (MOONSONG Study)

ABSTRACT Bemnifosbuvir is an oral antiviral drug with a dual mechanism of action targeting viral RNA polymerase, with in vitro activity against SARS-CoV-2. We conducted a phase 2, double-blind study evaluating the antiviral activity, safety, efficacy, and pharmacokinetics of bemnifosbuvir in ambulat...

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Bibliographic Details
Main Authors: Marta Boffito, Eamon Dolan, Karishma Singh, William Holmes, Steffen Wildum, Arantxa Horga, Keith Pietropaolo, Xiao-Jian Zhou, Barry Clinch, Neil Collinson, Vincent Ukachukwu
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
AT-527
COVID-19
SARS-CoV-2
bemnifosbuvir
direct-acting antiviral
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00077-23

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