Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development
Abstract Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persistence existence of leukemia stem cells...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-07-01
|
| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-021-00233-2 |
| _version_ | 1830510736650010624 |
|---|---|
| author | Yiyi Yao Fenglin Li Jiansong Huang Jie Jin Huafeng Wang |
| author_facet | Yiyi Yao Fenglin Li Jiansong Huang Jie Jin Huafeng Wang |
| author_sort | Yiyi Yao |
| collection | DOAJ |
| description | Abstract Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persistence existence of leukemia stem cells (LSCs). Bone marrow microenvironment (BMM), the home of hematopoiesis, has been considered to play a crucial role in both hematopoiesis and leukemogenesis. When interrupted by the AML cells, a malignant BMM formed and thus provided a refuge for LSCs and protecting them from the cytotoxic effects of chemotherapy. In this review, we summarized the alterations in the bidirectional interplay between hematopoietic cells and BMM in the normal/AML hematopoietic environment, and pointed out the key role of these alterations in pathogenesis and chemotherapy resistance of AML. Finally, we focused on the current potential BMM-targeted strategies together with future prospects and challenges. Accordingly, while further research is necessary to elucidate the underlying mechanisms behind LSC–BMM interaction, targeting the interaction is perceived as a potential therapeutic strategy to eradicate LSCs and ultimately improve the outcome of AML. |
| first_indexed | 2024-12-22T01:58:01Z |
| format | Article |
| id | doaj.art-45531155973a43bebed7a1edd8879d23 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-22T01:58:01Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-45531155973a43bebed7a1edd8879d232022-12-21T18:42:43ZengBMCExperimental Hematology & Oncology2162-36192021-07-0110111910.1186/s40164-021-00233-2Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia developmentYiyi Yao0Fenglin Li1Jiansong Huang2Jie Jin3Huafeng Wang4Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityAbstract Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persistence existence of leukemia stem cells (LSCs). Bone marrow microenvironment (BMM), the home of hematopoiesis, has been considered to play a crucial role in both hematopoiesis and leukemogenesis. When interrupted by the AML cells, a malignant BMM formed and thus provided a refuge for LSCs and protecting them from the cytotoxic effects of chemotherapy. In this review, we summarized the alterations in the bidirectional interplay between hematopoietic cells and BMM in the normal/AML hematopoietic environment, and pointed out the key role of these alterations in pathogenesis and chemotherapy resistance of AML. Finally, we focused on the current potential BMM-targeted strategies together with future prospects and challenges. Accordingly, while further research is necessary to elucidate the underlying mechanisms behind LSC–BMM interaction, targeting the interaction is perceived as a potential therapeutic strategy to eradicate LSCs and ultimately improve the outcome of AML.https://doi.org/10.1186/s40164-021-00233-2Acute myeloid leukemiaBone marrow microenvironmentLeukemia stem cellInteractionEnvironment-mediated drug resistance |
| spellingShingle | Yiyi Yao Fenglin Li Jiansong Huang Jie Jin Huafeng Wang Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development Experimental Hematology & Oncology Acute myeloid leukemia Bone marrow microenvironment Leukemia stem cell Interaction Environment-mediated drug resistance |
| title | Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development |
| title_full | Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development |
| title_fullStr | Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development |
| title_full_unstemmed | Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development |
| title_short | Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development |
| title_sort | leukemia stem cell bone marrow microenvironment interplay in acute myeloid leukemia development |
| topic | Acute myeloid leukemia Bone marrow microenvironment Leukemia stem cell Interaction Environment-mediated drug resistance |
| url | https://doi.org/10.1186/s40164-021-00233-2 |
| work_keys_str_mv | AT yiyiyao leukemiastemcellbonemarrowmicroenvironmentinterplayinacutemyeloidleukemiadevelopment AT fenglinli leukemiastemcellbonemarrowmicroenvironmentinterplayinacutemyeloidleukemiadevelopment AT jiansonghuang leukemiastemcellbonemarrowmicroenvironmentinterplayinacutemyeloidleukemiadevelopment AT jiejin leukemiastemcellbonemarrowmicroenvironmentinterplayinacutemyeloidleukemiadevelopment AT huafengwang leukemiastemcellbonemarrowmicroenvironmentinterplayinacutemyeloidleukemiadevelopment |