HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS
Aim. A controlled study was carried out regarding horizontal transmission of the vaccine strain of parotitic virus (PV). Materials and methods. 20 couples took part in the study. Monitoring of both spouses was carried out for 42 days after a single vaccination of one of them, levels of specific IgM...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2017-06-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.elpub.ru/jour/article/view/162 |
| _version_ | 1818081069651460096 |
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| author | E. V. Otrashevskaya M. V. Kulak E. K. Bukin M. A. Gorbunov G. M. Ignatyev |
| author_facet | E. V. Otrashevskaya M. V. Kulak E. K. Bukin M. A. Gorbunov G. M. Ignatyev |
| author_sort | E. V. Otrashevskaya |
| collection | DOAJ |
| description | Aim. A controlled study was carried out regarding horizontal transmission of the vaccine strain of parotitic virus (PV). Materials and methods. 20 couples took part in the study. Monitoring of both spouses was carried out for 42 days after a single vaccination of one of them, levels of specific IgM and IgG in sera and virus-neutralizing IgG in sera and saliva were studied in dynamics, PV RNA was also determined in sera and saliva samples. Amplified fragments of F, SH, NP and HN genes of PV were sequenced. Results. Transfer of PV vaccine strain was registered in all the couples except for one. Except a single contact spouse, all the rest demonstrated formation of a specific immune response. At month 4 of the observation, group of vaccinated spouses differed significantly from a group of contact spouses only by total content of specific IgG and their avidity. Conclusion. Horizontal transmission of PV strain was demonstrated in couples after vaccination of one of the spouses and resulted in formation of specific immunity in 95% of contact individuals. |
| first_indexed | 2024-12-10T19:00:21Z |
| format | Article |
| id | doaj.art-45538b66ff9b41e1adbff24311628027 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-12-10T19:00:21Z |
| publishDate | 2017-06-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-45538b66ff9b41e1adbff243116280272022-12-22T01:37:02ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132017-06-0103657110.36233/0372-9311-2017-3-65-71162HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTSE. V. Otrashevskaya0M. V. Kulak1E. K. Bukin2M. A. Gorbunov3G. M. Ignatyev4SPF «Microgen»SSC VB «Vector»SSC VB «Vector»Scientific Expert Centre for Means of Medical UseSPF «Microgen»Aim. A controlled study was carried out regarding horizontal transmission of the vaccine strain of parotitic virus (PV). Materials and methods. 20 couples took part in the study. Monitoring of both spouses was carried out for 42 days after a single vaccination of one of them, levels of specific IgM and IgG in sera and virus-neutralizing IgG in sera and saliva were studied in dynamics, PV RNA was also determined in sera and saliva samples. Amplified fragments of F, SH, NP and HN genes of PV were sequenced. Results. Transfer of PV vaccine strain was registered in all the couples except for one. Except a single contact spouse, all the rest demonstrated formation of a specific immune response. At month 4 of the observation, group of vaccinated spouses differed significantly from a group of contact spouses only by total content of specific IgG and their avidity. Conclusion. Horizontal transmission of PV strain was demonstrated in couples after vaccination of one of the spouses and resulted in formation of specific immunity in 95% of contact individuals.https://microbiol.elpub.ru/jour/article/view/162vaccine strain transmissionparotitis |
| spellingShingle | E. V. Otrashevskaya M. V. Kulak E. K. Bukin M. A. Gorbunov G. M. Ignatyev HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS Журнал микробиологии, эпидемиологии и иммунобиологии vaccine strain transmission parotitis |
| title | HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS |
| title_full | HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS |
| title_fullStr | HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS |
| title_full_unstemmed | HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS |
| title_short | HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS |
| title_sort | horizontal transmission of parotitis vaccine strain from vaccinated to close contacts |
| topic | vaccine strain transmission parotitis |
| url | https://microbiol.elpub.ru/jour/article/view/162 |
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