Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences

Fragments of prostatic acid phosphatase (PAP248-286) in human semen dramatically increase HIV infection efficiency by increasing virus adhesion to target cells. PAP248-286 only enhances HIV infection in the form of amyloid aggregates termed SEVI (Semen Enhancer of Viral Infection), however monomeric...

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Bibliographic Details
Main Authors: Kevin Hartman, Jeffrey R. Brender, Kazuaki Monde, Akira Ono, Margery L. Evans, Nataliya Popovych, Matthew R. Chapman, Ayyalusamy Ramamoorthy
Format: Article
Language:English
Published: PeerJ Inc. 2013-02-01
Series:PeerJ
Subjects:
Functional amyloid
Strain
Kinetics
Seeding
HIV
Online Access:https://peerj.com/articles/5.pdf

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