The role of secreted osteoclastogenic factor of activated T cells in bone remodeling
The process of bone remodeling is connected with the regulated balance between bone cell populations (including bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte). And the mechanism of bone remodeling activity is related to the major pathway, receptor activator of nuclear facto...
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
Elsevier
2022-11-01
|
| श्रृंखला: | Japanese Dental Science Review |
| विषय: | |
| ऑनलाइन पहुंच: | http://www.sciencedirect.com/science/article/pii/S1882761622000151 |
| _version_ | 1828087476071170048 |
|---|---|
| author | Ruonan Zhang Shuang Peng Guangxun Zhu |
| author_facet | Ruonan Zhang Shuang Peng Guangxun Zhu |
| author_sort | Ruonan Zhang |
| collection | DOAJ |
| description | The process of bone remodeling is connected with the regulated balance between bone cell populations (including bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte). And the mechanism of bone remodeling activity is related to the major pathway, receptor activator of nuclear factor kappaB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) signaling axis. Recently, researchers have found a novel cytokine secreted by activated T cells, which is related to osteoclastogenesis in the absence of osteoblasts or RANKL, leading to bone destruction. They name it the secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT has been proven to play an essential role in bone remodeling, like mediating the bone resorption in rheumatoid arthritis (RA) and periodontitis. In this review, we outline the latest research concerning SOFAT and discuss the characteristics, location, and regulation of SOFAT. We also summarize the clinical progress of SOFAT and assume the future therapeutic target in some diseases related to bone remodeling. |
| first_indexed | 2024-04-11T05:11:44Z |
| format | Article |
| id | doaj.art-4553f7613b2d4f988a3de7b032de1c7c |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-04-11T05:11:44Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-4553f7613b2d4f988a3de7b032de1c7c2022-12-25T04:17:26ZengElsevierJapanese Dental Science Review1882-76162022-11-0158227232The role of secreted osteoclastogenic factor of activated T cells in bone remodelingRuonan Zhang0Shuang Peng1Guangxun Zhu2Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorrespondence to: Department of Stomatology, Tongji Hospital, No.1095 Jiefang Road, Wuhan, Hubei 430030, China.; Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaThe process of bone remodeling is connected with the regulated balance between bone cell populations (including bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte). And the mechanism of bone remodeling activity is related to the major pathway, receptor activator of nuclear factor kappaB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) signaling axis. Recently, researchers have found a novel cytokine secreted by activated T cells, which is related to osteoclastogenesis in the absence of osteoblasts or RANKL, leading to bone destruction. They name it the secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT has been proven to play an essential role in bone remodeling, like mediating the bone resorption in rheumatoid arthritis (RA) and periodontitis. In this review, we outline the latest research concerning SOFAT and discuss the characteristics, location, and regulation of SOFAT. We also summarize the clinical progress of SOFAT and assume the future therapeutic target in some diseases related to bone remodeling.http://www.sciencedirect.com/science/article/pii/S1882761622000151Secreted osteoclastogenic factor of activated T cellsOsteoclastBone remodelingBone resorptionPeriodontal disease |
| spellingShingle | Ruonan Zhang Shuang Peng Guangxun Zhu The role of secreted osteoclastogenic factor of activated T cells in bone remodeling Japanese Dental Science Review Secreted osteoclastogenic factor of activated T cells Osteoclast Bone remodeling Bone resorption Periodontal disease |
| title | The role of secreted osteoclastogenic factor of activated T cells in bone remodeling |
| title_full | The role of secreted osteoclastogenic factor of activated T cells in bone remodeling |
| title_fullStr | The role of secreted osteoclastogenic factor of activated T cells in bone remodeling |
| title_full_unstemmed | The role of secreted osteoclastogenic factor of activated T cells in bone remodeling |
| title_short | The role of secreted osteoclastogenic factor of activated T cells in bone remodeling |
| title_sort | role of secreted osteoclastogenic factor of activated t cells in bone remodeling |
| topic | Secreted osteoclastogenic factor of activated T cells Osteoclast Bone remodeling Bone resorption Periodontal disease |
| url | http://www.sciencedirect.com/science/article/pii/S1882761622000151 |
| work_keys_str_mv | AT ruonanzhang theroleofsecretedosteoclastogenicfactorofactivatedtcellsinboneremodeling AT shuangpeng theroleofsecretedosteoclastogenicfactorofactivatedtcellsinboneremodeling AT guangxunzhu theroleofsecretedosteoclastogenicfactorofactivatedtcellsinboneremodeling AT ruonanzhang roleofsecretedosteoclastogenicfactorofactivatedtcellsinboneremodeling AT shuangpeng roleofsecretedosteoclastogenicfactorofactivatedtcellsinboneremodeling AT guangxunzhu roleofsecretedosteoclastogenicfactorofactivatedtcellsinboneremodeling |