A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease
Alzheimer's disease (AD) is one of the major worldwide causes of dementia that is characterized by irreversible decline in learning, memory loss, and behavioral impairments. Mitophagy is selective autophagy through the clearance of aberrant mitochondria, specifically for degradation to maintain...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.881239/full |
| _version_ | 1818252314051346432 |
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| author | Huiyi Chen Feng Chen Ying Jiang Lu Zhang Guizhen Hu Furong Sun Miaoping Zhang Yao Ji Yanting Chen Gang Che Gang Che Xu Zhou Yu Zhang |
| author_facet | Huiyi Chen Feng Chen Ying Jiang Lu Zhang Guizhen Hu Furong Sun Miaoping Zhang Yao Ji Yanting Chen Gang Che Gang Che Xu Zhou Yu Zhang |
| author_sort | Huiyi Chen |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is one of the major worldwide causes of dementia that is characterized by irreversible decline in learning, memory loss, and behavioral impairments. Mitophagy is selective autophagy through the clearance of aberrant mitochondria, specifically for degradation to maintain energy generation and neuronal and synaptic function in the brain. Accumulating evidence shows that defective mitophagy is believed to be as one of the early and prominent features in AD pathogenesis and has drawn attention in the recent few years. APOE ε4 allele is the greatest genetic determinant for AD and is widely reported to mediate detrimental effects on mitochondria function and mitophagic process. Given the continuity of the physiological process, this review takes the mitochondrial dynamic and mitophagic core events into consideration, which highlights the current knowledge about the molecular alterations from an APOE-genotype perspective, synthesizes ApoE4-associated regulations, and the cross-talk between these signaling, along with the focuses on general autophagic process and several pivotal processes of mitophagy, including mitochondrial dynamic (DRP1, MFN-1), mitophagic induction (PINK1, Parkin). These may shed new light on the link between ApoE4 and AD and provide novel insights for promising mitophagy-targeted therapeutic strategies for AD. |
| first_indexed | 2024-12-12T16:22:12Z |
| format | Article |
| id | doaj.art-4553f98515024c60bd800adce79e526a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T16:22:12Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4553f98515024c60bd800adce79e526a2022-12-22T00:18:57ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-05-011410.3389/fnagi.2022.881239881239A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's DiseaseHuiyi Chen0Feng Chen1Ying Jiang2Lu Zhang3Guizhen Hu4Furong Sun5Miaoping Zhang6Yao Ji7Yanting Chen8Gang Che9Gang Che10Xu Zhou11Yu Zhang12Department of Children Rehabilitation, Yuebei People's Hospital, Affiliated Hospital of Shantou University Medical College, Shaoguan, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Children Rehabilitation, Yuebei People's Hospital, Affiliated Hospital of Shantou University Medical College, Shaoguan, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Children Rehabilitation, Yuebei People's Hospital, Affiliated Hospital of Shantou University Medical College, Shaoguan, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Children Rehabilitation, Yuebei People's Hospital, Affiliated Hospital of Shantou University Medical College, Shaoguan, ChinaDepartment of Surgical Oncology, The First Affiliated Hospital, Zhejian University School of Medicine, Hangzhou, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaAlzheimer's disease (AD) is one of the major worldwide causes of dementia that is characterized by irreversible decline in learning, memory loss, and behavioral impairments. Mitophagy is selective autophagy through the clearance of aberrant mitochondria, specifically for degradation to maintain energy generation and neuronal and synaptic function in the brain. Accumulating evidence shows that defective mitophagy is believed to be as one of the early and prominent features in AD pathogenesis and has drawn attention in the recent few years. APOE ε4 allele is the greatest genetic determinant for AD and is widely reported to mediate detrimental effects on mitochondria function and mitophagic process. Given the continuity of the physiological process, this review takes the mitochondrial dynamic and mitophagic core events into consideration, which highlights the current knowledge about the molecular alterations from an APOE-genotype perspective, synthesizes ApoE4-associated regulations, and the cross-talk between these signaling, along with the focuses on general autophagic process and several pivotal processes of mitophagy, including mitochondrial dynamic (DRP1, MFN-1), mitophagic induction (PINK1, Parkin). These may shed new light on the link between ApoE4 and AD and provide novel insights for promising mitophagy-targeted therapeutic strategies for AD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.881239/fullAlzheimer's diseasemitophagymitochondrial dynamicsapolipoprotein Eneurodegenerative disease |
| spellingShingle | Huiyi Chen Feng Chen Ying Jiang Lu Zhang Guizhen Hu Furong Sun Miaoping Zhang Yao Ji Yanting Chen Gang Che Gang Che Xu Zhou Yu Zhang A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease Frontiers in Aging Neuroscience Alzheimer's disease mitophagy mitochondrial dynamics apolipoprotein E neurodegenerative disease |
| title | A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease |
| title_full | A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease |
| title_fullStr | A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease |
| title_full_unstemmed | A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease |
| title_short | A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease |
| title_sort | review of apoe4 interference targeting mitophagy molecular pathways for alzheimer s disease |
| topic | Alzheimer's disease mitophagy mitochondrial dynamics apolipoprotein E neurodegenerative disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.881239/full |
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