From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance
Recent efforts have concentrated on approaches to expand and “specify” human regulatory T cells (Tregs) and to apply them to modulate adverse immune responses in autoimmunity and hemophilia. We have used retroviral transduction of specific T-cell receptor, single chain Fv, or antigen domains in Treg...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01576/full |
| _version_ | 1828356852987985920 |
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| author | David W. Scott |
| author_facet | David W. Scott |
| author_sort | David W. Scott |
| collection | DOAJ |
| description | Recent efforts have concentrated on approaches to expand and “specify” human regulatory T cells (Tregs) and to apply them to modulate adverse immune responses in autoimmunity and hemophilia. We have used retroviral transduction of specific T-cell receptor, single chain Fv, or antigen domains in Tregs to achieve this goal. Each of these approaches have advantages and disadvantages. Results with these engineered T cells and evolution of the research developments and paths that led to the development of specific regulatory approaches for tolerance are summarized. |
| first_indexed | 2024-04-14T03:05:57Z |
| format | Article |
| id | doaj.art-45543c3663e24ce49ef7c5c73b987e3e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T03:05:57Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-45543c3663e24ce49ef7c5c73b987e3e2022-12-22T02:15:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01576317580From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of ToleranceDavid W. Scott0Department of Medicine, Uniformed Services University, Bethesda, MD, United StatesRecent efforts have concentrated on approaches to expand and “specify” human regulatory T cells (Tregs) and to apply them to modulate adverse immune responses in autoimmunity and hemophilia. We have used retroviral transduction of specific T-cell receptor, single chain Fv, or antigen domains in Tregs to achieve this goal. Each of these approaches have advantages and disadvantages. Results with these engineered T cells and evolution of the research developments and paths that led to the development of specific regulatory approaches for tolerance are summarized.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01576/fullregulatory T cellschimeric antigen receptorengineered T cellshemophilia Amultiple sclerosisB-cell receptor |
| spellingShingle | David W. Scott From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance Frontiers in Immunology regulatory T cells chimeric antigen receptor engineered T cells hemophilia A multiple sclerosis B-cell receptor |
| title | From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance |
| title_full | From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance |
| title_fullStr | From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance |
| title_full_unstemmed | From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance |
| title_short | From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance |
| title_sort | from igg fusion proteins to engineered specific human regulatory t cells a life of tolerance |
| topic | regulatory T cells chimeric antigen receptor engineered T cells hemophilia A multiple sclerosis B-cell receptor |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01576/full |
| work_keys_str_mv | AT davidwscott fromiggfusionproteinstoengineeredspecifichumanregulatorytcellsalifeoftolerance |