Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls
The study comprises evaluation of sodium and potassium in the pathogenesis of human gallstones as well as measurement of the concentration of these elements in gallstones and in sera of 109 gallstone subjects and 100 controls (age and sex matched with no personal or family history of gallstone disea...
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| Format: | Article |
| Language: | English |
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National Centre of Excellence in Analytical Chemsitry
2008-06-01
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| Series: | Pakistan Journal of Analytical & Environmental Chemistry |
| Subjects: | |
| Online Access: | http://www.ceacsu.edu.pk/PDF%20file/Journal%20Vol%209%20No%201/07-PJAEC-190608-19.pdf |
| _version_ | 1818444953578110976 |
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| author | Ali Mohammad Soomro Hidayatullah Mahessar Allah Bux Ghanghro Fatehuddin Khand Naseem Aslam Channa |
| author_facet | Ali Mohammad Soomro Hidayatullah Mahessar Allah Bux Ghanghro Fatehuddin Khand Naseem Aslam Channa |
| author_sort | Ali Mohammad Soomro |
| collection | DOAJ |
| description | The study comprises evaluation of sodium and potassium in the pathogenesis of human gallstones as well as measurement of the concentration of these elements in gallstones and in sera of 109 gallstone subjects and 100 controls (age and sex matched with no personal or family history of gallstone disease). It was observed that serum concentrations for both sodium and potassium were comparable (p>0.05) between gallstone subjects and control subjects. In gallstones the concentration of sodium was significantly higher as compared to potassium (p<0.05). Normal sodium to potassium ratio was seen in serum of gallstone subjects, whereas, low sodium to potassium ratio was seen in gallstone carriers. Amongst the different types of gallstones, significantly high (p<0.05) concentrations of sodium and potassium were seen in calcium bilirubinate gallstones. The levels for these mineral elements were also raised in serum of pure calcium carbonate gallstone subjects.The results demonstrate that the higher concentration of sodium and potassium in gallstones may involve in both calcium bilirubinate gallstones and in serum of calcium carbonate gallstone subjects, which indicate their association with calcium in the precipitation of calcium bilirubinate and calcium carbonate in bile. Furthermore, low sodium to potassium ratio in gallstones indicates low ratio in bile of gallstone subjects. |
| first_indexed | 2024-12-14T19:24:08Z |
| format | Article |
| id | doaj.art-4555400e361444489dbadb9c9e5f7140 |
| institution | Directory Open Access Journal |
| issn | 1996-918X 2221-5255 |
| language | English |
| last_indexed | 2024-12-14T19:24:08Z |
| publishDate | 2008-06-01 |
| publisher | National Centre of Excellence in Analytical Chemsitry |
| record_format | Article |
| series | Pakistan Journal of Analytical & Environmental Chemistry |
| spelling | doaj.art-4555400e361444489dbadb9c9e5f71402022-12-21T22:50:15ZengNational Centre of Excellence in Analytical ChemsitryPakistan Journal of Analytical & Environmental Chemistry1996-918X2221-52552008-06-01913842Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and ControlsAli Mohammad SoomroHidayatullah MahessarAllah Bux GhanghroFatehuddin KhandNaseem Aslam ChannaThe study comprises evaluation of sodium and potassium in the pathogenesis of human gallstones as well as measurement of the concentration of these elements in gallstones and in sera of 109 gallstone subjects and 100 controls (age and sex matched with no personal or family history of gallstone disease). It was observed that serum concentrations for both sodium and potassium were comparable (p>0.05) between gallstone subjects and control subjects. In gallstones the concentration of sodium was significantly higher as compared to potassium (p<0.05). Normal sodium to potassium ratio was seen in serum of gallstone subjects, whereas, low sodium to potassium ratio was seen in gallstone carriers. Amongst the different types of gallstones, significantly high (p<0.05) concentrations of sodium and potassium were seen in calcium bilirubinate gallstones. The levels for these mineral elements were also raised in serum of pure calcium carbonate gallstone subjects.The results demonstrate that the higher concentration of sodium and potassium in gallstones may involve in both calcium bilirubinate gallstones and in serum of calcium carbonate gallstone subjects, which indicate their association with calcium in the precipitation of calcium bilirubinate and calcium carbonate in bile. Furthermore, low sodium to potassium ratio in gallstones indicates low ratio in bile of gallstone subjects.http://www.ceacsu.edu.pk/PDF%20file/Journal%20Vol%209%20No%201/07-PJAEC-190608-19.pdfgallastonescalciumprecipitationsodium to potassium ratio in gallstones |
| spellingShingle | Ali Mohammad Soomro Hidayatullah Mahessar Allah Bux Ghanghro Fatehuddin Khand Naseem Aslam Channa Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls Pakistan Journal of Analytical & Environmental Chemistry gallastones calcium precipitation sodium to potassium ratio in gallstones |
| title | Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls |
| title_full | Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls |
| title_fullStr | Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls |
| title_full_unstemmed | Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls |
| title_short | Comparative Study of Sodium and Potassium in Different Types of Gallstones and in Serum of Subjects with Gallstones and Controls |
| title_sort | comparative study of sodium and potassium in different types of gallstones and in serum of subjects with gallstones and controls |
| topic | gallastones calcium precipitation sodium to potassium ratio in gallstones |
| url | http://www.ceacsu.edu.pk/PDF%20file/Journal%20Vol%209%20No%201/07-PJAEC-190608-19.pdf |
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