Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury
Increasing evidence indicates that mitochondrial fission imbalance plays an important role in delayed neuronal cell death. Our previous study found that photobiomodulation improved the motor function of rats with spinal cord injury. However, the precise mechanism remains unclear. To investigate the...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2005;epage=2010;aulast=Li |
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| author | Xin Li Xuan-Kang Wang Zhi-Jie Zhu Zhuo-Wen Liang Peng-Hui Li Yang-Guang Ma Tan Ding Kun Li Xiao-Shuang Zuo Cheng Ju Zhi-Hao Zhang Zhi-Wen Song Hui-Lin Quan Jia-Wei Zhang Liang Luo Zhe Wang Xue-Yu Hu |
| author_facet | Xin Li Xuan-Kang Wang Zhi-Jie Zhu Zhuo-Wen Liang Peng-Hui Li Yang-Guang Ma Tan Ding Kun Li Xiao-Shuang Zuo Cheng Ju Zhi-Hao Zhang Zhi-Wen Song Hui-Lin Quan Jia-Wei Zhang Liang Luo Zhe Wang Xue-Yu Hu |
| author_sort | Xin Li |
| collection | DOAJ |
| description | Increasing evidence indicates that mitochondrial fission imbalance plays an important role in delayed neuronal cell death. Our previous study found that photobiomodulation improved the motor function of rats with spinal cord injury. However, the precise mechanism remains unclear. To investigate the effect of photobiomodulation on mitochondrial fission imbalance after spinal cord injury, in this study, we treated rat models of spinal cord injury with 60-minute photobiomodulation (810 nm, 150 mW) every day for 14 consecutive days. Transmission electron microscopy results confirmed the swollen and fragmented alterations of mitochondrial morphology in neurons in acute (1 day) and subacute (7 and 14 days) phases. Photobiomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase, reduced neuronal cell death, and improved rat posterior limb motor function in a time-dependent manner. These findings suggest that photobiomodulation targets neuronal mitochondria, alleviates mitochondrial fission imbalance-induced neuronal apoptosis, and thereby promotes the motor function recovery of rats with spinal cord injury. |
| first_indexed | 2024-04-09T23:23:58Z |
| format | Article |
| id | doaj.art-4555938627d841ed87aaad43f43fbe93 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-09T23:23:58Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-4555938627d841ed87aaad43f43fbe932023-03-21T11:23:56ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-011892005201010.4103/1673-5374.366491Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injuryXin LiXuan-Kang WangZhi-Jie ZhuZhuo-Wen LiangPeng-Hui LiYang-Guang MaTan DingKun LiXiao-Shuang ZuoCheng JuZhi-Hao ZhangZhi-Wen SongHui-Lin QuanJia-Wei ZhangLiang LuoZhe WangXue-Yu HuIncreasing evidence indicates that mitochondrial fission imbalance plays an important role in delayed neuronal cell death. Our previous study found that photobiomodulation improved the motor function of rats with spinal cord injury. However, the precise mechanism remains unclear. To investigate the effect of photobiomodulation on mitochondrial fission imbalance after spinal cord injury, in this study, we treated rat models of spinal cord injury with 60-minute photobiomodulation (810 nm, 150 mW) every day for 14 consecutive days. Transmission electron microscopy results confirmed the swollen and fragmented alterations of mitochondrial morphology in neurons in acute (1 day) and subacute (7 and 14 days) phases. Photobiomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase, reduced neuronal cell death, and improved rat posterior limb motor function in a time-dependent manner. These findings suggest that photobiomodulation targets neuronal mitochondria, alleviates mitochondrial fission imbalance-induced neuronal apoptosis, and thereby promotes the motor function recovery of rats with spinal cord injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2005;epage=2010;aulast=Lilow-level laser therapy; mitochondria; mitochondrial dynamics; mitochondrial fission imbalance; neuron; photobiomodulation; secondary injury; spinal cord injury |
| spellingShingle | Xin Li Xuan-Kang Wang Zhi-Jie Zhu Zhuo-Wen Liang Peng-Hui Li Yang-Guang Ma Tan Ding Kun Li Xiao-Shuang Zuo Cheng Ju Zhi-Hao Zhang Zhi-Wen Song Hui-Lin Quan Jia-Wei Zhang Liang Luo Zhe Wang Xue-Yu Hu Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury Neural Regeneration Research low-level laser therapy; mitochondria; mitochondrial dynamics; mitochondrial fission imbalance; neuron; photobiomodulation; secondary injury; spinal cord injury |
| title | Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury |
| title_full | Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury |
| title_fullStr | Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury |
| title_full_unstemmed | Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury |
| title_short | Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury |
| title_sort | photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury |
| topic | low-level laser therapy; mitochondria; mitochondrial dynamics; mitochondrial fission imbalance; neuron; photobiomodulation; secondary injury; spinal cord injury |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2005;epage=2010;aulast=Li |
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