Fetuin-A levels in hyperthyroidism
OBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measure...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2013-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300016 |
| _version_ | 1811330763516280832 |
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| author | Bariş Onder Pamuk Hamiyet Yilmaz Tugba Topcuoglu Oktay Bilgir Ozlem Çalan Gulseren Pamuk Derun Taner Ertugrul |
| author_facet | Bariş Onder Pamuk Hamiyet Yilmaz Tugba Topcuoglu Oktay Bilgir Ozlem Çalan Gulseren Pamuk Derun Taner Ertugrul |
| author_sort | Bariş Onder Pamuk |
| collection | DOAJ |
| description | OBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS: Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p<0.0001), insulin (r:0.479, p:0.001), homeostasis model of assessment-insulin resistance (r:0.541, p<0.0001), fT3 (r:0.492, p:0.001) and fT4 (r:0.473, p:0.002) were positively correlated with basal fetuin-A levels. Basal thyrotropin levels were significantly negatively correlated (r:-0.553, p<0.0001) with basal fetuin-A levels. CONCLUSION: Our findings suggest that hyperthyroidism influences fetuin-A levels. |
| first_indexed | 2024-04-13T16:08:45Z |
| format | Article |
| id | doaj.art-4556107930764deaa7b44aa5899da328 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T16:08:45Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-4556107930764deaa7b44aa5899da3282022-12-22T02:40:19ZengElsevier EspañaClinics1807-59321980-53222013-01-01683379383Fetuin-A levels in hyperthyroidismBari&#351; Onder PamukHamiyet YilmazTugba TopcuogluOktay BilgirOzlem &#199;alanGulseren PamukDerun Taner ErtugrulOBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS: Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p<0.0001), insulin (r:0.479, p:0.001), homeostasis model of assessment-insulin resistance (r:0.541, p<0.0001), fT3 (r:0.492, p:0.001) and fT4 (r:0.473, p:0.002) were positively correlated with basal fetuin-A levels. Basal thyrotropin levels were significantly negatively correlated (r:-0.553, p<0.0001) with basal fetuin-A levels. CONCLUSION: Our findings suggest that hyperthyroidism influences fetuin-A levels.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300016Fetuin-AHyperthyroidismInsulin Resistance |
| spellingShingle | Bari&#351; Onder Pamuk Hamiyet Yilmaz Tugba Topcuoglu Oktay Bilgir Ozlem &#199;alan Gulseren Pamuk Derun Taner Ertugrul Fetuin-A levels in hyperthyroidism Clinics Fetuin-A Hyperthyroidism Insulin Resistance |
| title | Fetuin-A levels in hyperthyroidism |
| title_full | Fetuin-A levels in hyperthyroidism |
| title_fullStr | Fetuin-A levels in hyperthyroidism |
| title_full_unstemmed | Fetuin-A levels in hyperthyroidism |
| title_short | Fetuin-A levels in hyperthyroidism |
| title_sort | fetuin a levels in hyperthyroidism |
| topic | Fetuin-A Hyperthyroidism Insulin Resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300016 |
| work_keys_str_mv | AT bariamp351onderpamuk fetuinalevelsinhyperthyroidism AT hamiyetyilmaz fetuinalevelsinhyperthyroidism AT tugbatopcuoglu fetuinalevelsinhyperthyroidism AT oktaybilgir fetuinalevelsinhyperthyroidism AT ozlemamp199alan fetuinalevelsinhyperthyroidism AT gulserenpamuk fetuinalevelsinhyperthyroidism AT deruntanerertugrul fetuinalevelsinhyperthyroidism |