Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility
Thrombocytes play an essential role in hemostasis and thrombosis. Moreover, the controlled activation of thrombocytes is required in reproduction and fertility. The platelet-activating factor and the controlled activation of platelets have important roles in folliculogenesis, ovulation, placental de...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/24/17336 |
| _version_ | 1797380757052719104 |
|---|---|
| author | Bernadett Nagy Kálmán Kovács Endre Sulyok Ákos Várnagy József Bódis |
| author_facet | Bernadett Nagy Kálmán Kovács Endre Sulyok Ákos Várnagy József Bódis |
| author_sort | Bernadett Nagy |
| collection | DOAJ |
| description | Thrombocytes play an essential role in hemostasis and thrombosis. Moreover, the controlled activation of thrombocytes is required in reproduction and fertility. The platelet-activating factor and the controlled activation of platelets have important roles in folliculogenesis, ovulation, placental development, implantation and embryo development. Activated platelets accumulate in the follicular vessels surrounding the follicle and, due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters), locally increase oocyte maturation and hormone secretion. Furthermore, activated platelets are involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS) and preeclampsia. Low-dose aspirin can prevent OHSS during ovulation induction, while intrauterine or intraovarian administration of platelet-rich plasma (PRP) increases the endometrium thickness and receptivity as well as oocyte maturation. Activated thrombocytes rapidly release the contents of intracellular granules and have multiple adhesion molecules and receptors on their surface. Considering the numerous homeostatic endocrine functions of thrombocytes, it is reasonable to suppose a platelet-associated regulatory system (PARS) in reproduction. Although we are far from a complete understanding of the regulatory processes, the results of PARS research and the therapeutic application of aspirin and PRP during in vitro fertilization are promising. |
| first_indexed | 2024-03-08T20:41:40Z |
| format | Article |
| id | doaj.art-45561ab3baf54434a0951e0181598991 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:41:40Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-45561ab3baf54434a0951e01815989912023-12-22T14:14:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241733610.3390/ijms242417336Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and FertilityBernadett Nagy0Kálmán Kovács1Endre Sulyok2Ákos Várnagy3József Bódis4National Laboratory on Human Reproduction, 7624 Pécs, HungaryNational Laboratory on Human Reproduction, 7624 Pécs, HungaryNational Laboratory on Human Reproduction, 7624 Pécs, HungaryNational Laboratory on Human Reproduction, 7624 Pécs, HungaryNational Laboratory on Human Reproduction, 7624 Pécs, HungaryThrombocytes play an essential role in hemostasis and thrombosis. Moreover, the controlled activation of thrombocytes is required in reproduction and fertility. The platelet-activating factor and the controlled activation of platelets have important roles in folliculogenesis, ovulation, placental development, implantation and embryo development. Activated platelets accumulate in the follicular vessels surrounding the follicle and, due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters), locally increase oocyte maturation and hormone secretion. Furthermore, activated platelets are involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS) and preeclampsia. Low-dose aspirin can prevent OHSS during ovulation induction, while intrauterine or intraovarian administration of platelet-rich plasma (PRP) increases the endometrium thickness and receptivity as well as oocyte maturation. Activated thrombocytes rapidly release the contents of intracellular granules and have multiple adhesion molecules and receptors on their surface. Considering the numerous homeostatic endocrine functions of thrombocytes, it is reasonable to suppose a platelet-associated regulatory system (PARS) in reproduction. Although we are far from a complete understanding of the regulatory processes, the results of PARS research and the therapeutic application of aspirin and PRP during in vitro fertilization are promising.https://www.mdpi.com/1422-0067/24/24/17336thrombocytesreproductionfertilityin vitro fertilizationpreeclampsiaaspirin |
| spellingShingle | Bernadett Nagy Kálmán Kovács Endre Sulyok Ákos Várnagy József Bódis Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility International Journal of Molecular Sciences thrombocytes reproduction fertility in vitro fertilization preeclampsia aspirin |
| title | Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility |
| title_full | Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility |
| title_fullStr | Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility |
| title_full_unstemmed | Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility |
| title_short | Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility |
| title_sort | thrombocytes and platelet rich plasma as modulators of reproduction and fertility |
| topic | thrombocytes reproduction fertility in vitro fertilization preeclampsia aspirin |
| url | https://www.mdpi.com/1422-0067/24/24/17336 |
| work_keys_str_mv | AT bernadettnagy thrombocytesandplateletrichplasmaasmodulatorsofreproductionandfertility AT kalmankovacs thrombocytesandplateletrichplasmaasmodulatorsofreproductionandfertility AT endresulyok thrombocytesandplateletrichplasmaasmodulatorsofreproductionandfertility AT akosvarnagy thrombocytesandplateletrichplasmaasmodulatorsofreproductionandfertility AT jozsefbodis thrombocytesandplateletrichplasmaasmodulatorsofreproductionandfertility |