<i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone
<i>Mycoplasma</i> (<i>M</i>.) <i>bovis</i> is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced s...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/11/875 |
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| author | Florence Tardy Anna Aspan Tiina Autio Anne Ridley Agnès Tricot Adélie Colin Tarja Pohjanvirta Bregtje Smid Frank Harders Mikkel Lindegaard Klara Tølbøll Lauritsen Ulrike Lyhs Henk J. Wisselink Mikael Lenz Strube |
| author_facet | Florence Tardy Anna Aspan Tiina Autio Anne Ridley Agnès Tricot Adélie Colin Tarja Pohjanvirta Bregtje Smid Frank Harders Mikkel Lindegaard Klara Tølbøll Lauritsen Ulrike Lyhs Henk J. Wisselink Mikael Lenz Strube |
| author_sort | Florence Tardy |
| collection | DOAJ |
| description | <i>Mycoplasma</i> (<i>M</i>.) <i>bovis</i> is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organism has contributed to difficulties in controlling infection. Despite global presence, some countries have only recently experienced outbreaks of this pathogen. In the present study, <i>M. bovis</i> isolates collected in Denmark between 1981 and 2016 were characterized to determine (i) genetic diversity and phylogenetic relationships using whole genome sequencing and various sequence-based typing methods and (ii) patterns of antimicrobial resistance compared to other European isolates. The <i>M. bovis</i> population in Denmark was found to be highly homogeneous genomically and with respect to the antimicrobial resistance profile. Previously dominated by an old genotype shared by many other countries (ST17 in the PubMLST legacy scheme), a new predominant type represented by ST94-<i>adh1</i> has emerged. The same clone is also found in Sweden and Finland, where <i>M. bovis</i> introduction is more recent. Although retrieved from the Netherlands, it appears absent from France, two countries with a long history of <i>M. bovis</i> infection where the <i>M. bovis</i> population is more diverse. |
| first_indexed | 2024-03-10T15:22:32Z |
| format | Article |
| id | doaj.art-4556d5ff02494da7866558e592c766ef |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T15:22:32Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-4556d5ff02494da7866558e592c766ef2023-11-20T18:22:11ZengMDPI AGPathogens2076-08172020-10-0191187510.3390/pathogens9110875<i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New CloneFlorence Tardy0Anna Aspan1Tiina Autio2Anne Ridley3Agnès Tricot4Adélie Colin5Tarja Pohjanvirta6Bregtje Smid7Frank Harders8Mikkel Lindegaard9Klara Tølbøll Lauritsen10Ulrike Lyhs11Henk J. Wisselink12Mikael Lenz Strube13UMR Mycoplasmoses des Ruminants, ANSES laboratoire de Lyon, VetAgro Sup, Université de Lyon, 69364 Lyon, FranceNational Veterinary Institute (SVA), SE-751 89 Uppsala, SwedenFinnish Food Authority, 70210 Kuopio, FinlandAnimal and Plant Health Agency (APHA), Surrey KT15 3NB, UKUMR Mycoplasmoses des Ruminants, ANSES laboratoire de Lyon, VetAgro Sup, Université de Lyon, 69364 Lyon, FranceUMR Mycoplasmoses des Ruminants, ANSES laboratoire de Lyon, VetAgro Sup, Université de Lyon, 69364 Lyon, FranceFinnish Food Authority, 70210 Kuopio, FinlandWageningen Bioveterinary Research, 8221 RA Lelystad, The NetherlandsWageningen Bioveterinary Research, 8221 RA Lelystad, The NetherlandsNational Veterinary Institute, Technical University of Denmark, 2800 Kgs Lyngby, DenmarkNational Veterinary Institute, Technical University of Denmark, 2800 Kgs Lyngby, DenmarkNational Veterinary Institute, Technical University of Denmark, 2800 Kgs Lyngby, DenmarkWageningen Bioveterinary Research, 8221 RA Lelystad, The NetherlandsNational Veterinary Institute, Technical University of Denmark, 2800 Kgs Lyngby, Denmark<i>Mycoplasma</i> (<i>M</i>.) <i>bovis</i> is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organism has contributed to difficulties in controlling infection. Despite global presence, some countries have only recently experienced outbreaks of this pathogen. In the present study, <i>M. bovis</i> isolates collected in Denmark between 1981 and 2016 were characterized to determine (i) genetic diversity and phylogenetic relationships using whole genome sequencing and various sequence-based typing methods and (ii) patterns of antimicrobial resistance compared to other European isolates. The <i>M. bovis</i> population in Denmark was found to be highly homogeneous genomically and with respect to the antimicrobial resistance profile. Previously dominated by an old genotype shared by many other countries (ST17 in the PubMLST legacy scheme), a new predominant type represented by ST94-<i>adh1</i> has emerged. The same clone is also found in Sweden and Finland, where <i>M. bovis</i> introduction is more recent. Although retrieved from the Netherlands, it appears absent from France, two countries with a long history of <i>M. bovis</i> infection where the <i>M. bovis</i> population is more diverse.https://www.mdpi.com/2076-0817/9/11/875cattleantimicrobial resistancegenomic epidemiologyphylogenetics<i>Mycoplasma bovis</i> |
| spellingShingle | Florence Tardy Anna Aspan Tiina Autio Anne Ridley Agnès Tricot Adélie Colin Tarja Pohjanvirta Bregtje Smid Frank Harders Mikkel Lindegaard Klara Tølbøll Lauritsen Ulrike Lyhs Henk J. Wisselink Mikael Lenz Strube <i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone Pathogens cattle antimicrobial resistance genomic epidemiology phylogenetics <i>Mycoplasma bovis</i> |
| title | <i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone |
| title_full | <i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone |
| title_fullStr | <i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone |
| title_full_unstemmed | <i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone |
| title_short | <i>Mycoplasma bovis</i> in Nordic European Countries: Emergence and Dominance of a New Clone |
| title_sort | i mycoplasma bovis i in nordic european countries emergence and dominance of a new clone |
| topic | cattle antimicrobial resistance genomic epidemiology phylogenetics <i>Mycoplasma bovis</i> |
| url | https://www.mdpi.com/2076-0817/9/11/875 |
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