Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review
Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Obj...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.620863/full |
| _version_ | 1819121260532072448 |
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| author | Taewon Kim Christine Park Pratik Y. Chhatbar Jody Feld Brian Mac Grory Chang S. Nam Pu Wang Mengyue Chen Xiaoning Jiang Wuwei Feng |
| author_facet | Taewon Kim Christine Park Pratik Y. Chhatbar Jody Feld Brian Mac Grory Chang S. Nam Pu Wang Mengyue Chen Xiaoning Jiang Wuwei Feng |
| author_sort | Taewon Kim |
| collection | DOAJ |
| description | Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Objective: In this review, we summarized the findings reported by recently published studies regarding the effect of LI-TUS on neuromodulation in both animals and humans. We also aim to identify challenges and opportunities for the translation process.Methods: A literature search of PubMed, Medline, EMBASE, and Web of Science was performed from January 2019 to June 2020 with the following keywords and Boolean operators: [transcranial ultrasound OR transcranial focused ultrasound OR ultrasound stimulation] AND [neuromodulation]. The methodological quality of the animal studies was assessed by the SYRCLE's risk of bias tool, and the quality of human studies was evaluated by the PEDro score and the NIH quality assessment tool.Results: After applying the inclusion and exclusion criteria, a total of 26 manuscripts (24 animal studies and two human studies) out of 508 reports were included in this systematic review. Although both inhibitory (10 studies) and excitatory (16 studies) effects of LI-TUS were observed in animal studies, only inhibitory effects have been reported in primates (five studies) and human subjects (two studies). The ultrasonic parameters used in animal and human studies are different. The SYRCLE quality score ranged from 25 to 43%, with a majority of the low scores related to performance and detection bias. The two human studies received high PEDro scores (9/10).Conclusion: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans. Further human studies are needed to more precisely define the effective modulation parameters and thereby translate this brain modulatory tool into the clinic. |
| first_indexed | 2024-12-22T06:33:44Z |
| format | Article |
| id | doaj.art-455798b2bde34eec9bd93ebb8c8895d7 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T06:33:44Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-455798b2bde34eec9bd93ebb8c8895d72022-12-21T18:35:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-04-011510.3389/fnins.2021.620863620863Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic ReviewTaewon Kim0Christine Park1Pratik Y. Chhatbar2Jody Feld3Brian Mac Grory4Chang S. Nam5Pu Wang6Mengyue Chen7Xiaoning Jiang8Wuwei Feng9Department of Neurology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Neurology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Neurology, Duke University School of Medicine, Durham, NC, United StatesPhysical Therapy Division, Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United StatesDepartment of Neurology, Duke University School of Medicine, Durham, NC, United StatesFitts Department of Industrial and Systems Engineering, North Carolina State University, Raleigh, NC, United StatesDepartment of Rehabilitation Medicine, Seventh Affiliated Hospital, Sun Yat-sen University, Shengzhen, ChinaDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, United StatesDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, United StatesDepartment of Neurology, Duke University School of Medicine, Durham, NC, United StatesBackground: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Objective: In this review, we summarized the findings reported by recently published studies regarding the effect of LI-TUS on neuromodulation in both animals and humans. We also aim to identify challenges and opportunities for the translation process.Methods: A literature search of PubMed, Medline, EMBASE, and Web of Science was performed from January 2019 to June 2020 with the following keywords and Boolean operators: [transcranial ultrasound OR transcranial focused ultrasound OR ultrasound stimulation] AND [neuromodulation]. The methodological quality of the animal studies was assessed by the SYRCLE's risk of bias tool, and the quality of human studies was evaluated by the PEDro score and the NIH quality assessment tool.Results: After applying the inclusion and exclusion criteria, a total of 26 manuscripts (24 animal studies and two human studies) out of 508 reports were included in this systematic review. Although both inhibitory (10 studies) and excitatory (16 studies) effects of LI-TUS were observed in animal studies, only inhibitory effects have been reported in primates (five studies) and human subjects (two studies). The ultrasonic parameters used in animal and human studies are different. The SYRCLE quality score ranged from 25 to 43%, with a majority of the low scores related to performance and detection bias. The two human studies received high PEDro scores (9/10).Conclusion: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans. Further human studies are needed to more precisely define the effective modulation parameters and thereby translate this brain modulatory tool into the clinic.https://www.frontiersin.org/articles/10.3389/fnins.2021.620863/fullultrasoundlow intensity transcranial ultrasound stimulationnon-invasive brain stimulationneuromodulationhumananimal |
| spellingShingle | Taewon Kim Christine Park Pratik Y. Chhatbar Jody Feld Brian Mac Grory Chang S. Nam Pu Wang Mengyue Chen Xiaoning Jiang Wuwei Feng Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review Frontiers in Neuroscience ultrasound low intensity transcranial ultrasound stimulation non-invasive brain stimulation neuromodulation human animal |
| title | Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review |
| title_full | Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review |
| title_fullStr | Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review |
| title_full_unstemmed | Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review |
| title_short | Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review |
| title_sort | effect of low intensity transcranial ultrasound stimulation on neuromodulation in animals and humans an updated systematic review |
| topic | ultrasound low intensity transcranial ultrasound stimulation non-invasive brain stimulation neuromodulation human animal |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.620863/full |
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