ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
Abstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/280 |
| _version_ | 1826534316848447488 |
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| author | N. A. Ilyina E. V. Goiman O. T. Kudaeva O. P. Kolesnikova V. S. Kozhevnikov |
| author_facet | N. A. Ilyina E. V. Goiman O. T. Kudaeva O. P. Kolesnikova V. S. Kozhevnikov |
| author_sort | N. A. Ilyina |
| collection | DOAJ |
| description | Abstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated syngeneic splenocytes to induce anti-ergotypic response and to assess immune response in delayed-type hypersensitivity (DTH) reaction.DTH response in experimental group was significantly greater than in control and intact groups. Upon crossadministration, DTH response was minimal and there were no significant differences between the groups. No changes in cellular and humoral immune response were observed under such conditions. These results suggest a development of immune response to activated antigen-nonspecific cells. In a model of chronic GvHD, donor immunization was shown to exert a protective effect, with regard of proteinuria dynamics in recipients, whereas immunization of recipients did not alter the GvHD dynamics. (Med. Immunol., 2011, vol. 13, N 1, pp 29-34) |
| first_indexed | 2024-03-08T05:51:29Z |
| format | Article |
| id | doaj.art-4557b1bd745244b19723be9fc207990e |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:21:05Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-4557b1bd745244b19723be9fc207990e2025-03-11T17:59:01ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01131293410.15789/1563-0625-2011-1-29-34277ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODELN. A. Ilyina0E. V. Goiman1O. T. Kudaeva2O. P. Kolesnikova3V. S. Kozhevnikov4НИИКИ СО РАМН, г. НовосибирскНИИКИ СО РАМН, г. НовосибирскНИИКИ СО РАМН, г. НовосибирскНИИКИ СО РАМН, г. НовосибирскНИИКИ СО РАМН, г. НовосибирскAbstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated syngeneic splenocytes to induce anti-ergotypic response and to assess immune response in delayed-type hypersensitivity (DTH) reaction.DTH response in experimental group was significantly greater than in control and intact groups. Upon crossadministration, DTH response was minimal and there were no significant differences between the groups. No changes in cellular and humoral immune response were observed under such conditions. These results suggest a development of immune response to activated antigen-nonspecific cells. In a model of chronic GvHD, donor immunization was shown to exert a protective effect, with regard of proteinuria dynamics in recipients, whereas immunization of recipients did not alter the GvHD dynamics. (Med. Immunol., 2011, vol. 13, N 1, pp 29-34)https://www.mimmun.ru/mimmun/article/view/280ртпхгзтантиэрготипический ответактивированные спленоциты |
| spellingShingle | N. A. Ilyina E. V. Goiman O. T. Kudaeva O. P. Kolesnikova V. S. Kozhevnikov ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL Медицинская иммунология ртпх гзт антиэрготипический ответ активированные спленоциты |
| title | ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL |
| title_full | ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL |
| title_fullStr | ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL |
| title_full_unstemmed | ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL |
| title_short | ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL |
| title_sort | anti ergotypic response role in normal immune response and autoimmune pathology in experimental model |
| topic | ртпх гзт антиэрготипический ответ активированные спленоциты |
| url | https://www.mimmun.ru/mimmun/article/view/280 |
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