Nutritional Supplements for the Treatment of Neuropathic Pain
Neuropathic pain affects 7–10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake inhibitors, and anticonvulsants, patients suffering from neur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/6/674 |
| _version_ | 1797530239800180736 |
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| author | Khaled M. Abdelrahman Kevin V. Hackshaw |
| author_facet | Khaled M. Abdelrahman Kevin V. Hackshaw |
| author_sort | Khaled M. Abdelrahman |
| collection | DOAJ |
| description | Neuropathic pain affects 7–10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake inhibitors, and anticonvulsants, patients suffering from neuropathic pain are increasingly turning to nonpharmacologic treatments, including nutritional supplements for analgesia. So-called “nutraceuticals” have garnered significant interest among patients seeking to self-treat their neuropathic pain with readily available supplements. The supplements most often used by patients include vitamins such as vitamin B and vitamin D, trace minerals zinc and magnesium, and herbal remedies such as curcumin and St. John’s Wort. However, evidence surrounding the efficacy and mechanisms of these supplements in neuropathic pain is limited, and the scientific literature consists primarily of preclinical animal models, case studies, and small randomized controlled trials (RCTs). Further exploration into large randomized controlled trials is needed to fully inform patients and physicians on the utility of these supplements in neuropathic pain. In this review, we explore the basis behind using several nutritional supplements commonly used by patients with neuropathic pain seen in rheumatology clinics. |
| first_indexed | 2024-03-10T10:26:12Z |
| format | Article |
| id | doaj.art-4558c4dade66467f8f3fbb0664ec5453 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T10:26:12Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4558c4dade66467f8f3fbb0664ec54532023-11-21T23:58:54ZengMDPI AGBiomedicines2227-90592021-06-019667410.3390/biomedicines9060674Nutritional Supplements for the Treatment of Neuropathic PainKhaled M. Abdelrahman0Kevin V. Hackshaw1Dell Medical School, University of Texas at Austin, Austin, TX 78712, USADell Medical School, University of Texas at Austin, Austin, TX 78712, USANeuropathic pain affects 7–10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake inhibitors, and anticonvulsants, patients suffering from neuropathic pain are increasingly turning to nonpharmacologic treatments, including nutritional supplements for analgesia. So-called “nutraceuticals” have garnered significant interest among patients seeking to self-treat their neuropathic pain with readily available supplements. The supplements most often used by patients include vitamins such as vitamin B and vitamin D, trace minerals zinc and magnesium, and herbal remedies such as curcumin and St. John’s Wort. However, evidence surrounding the efficacy and mechanisms of these supplements in neuropathic pain is limited, and the scientific literature consists primarily of preclinical animal models, case studies, and small randomized controlled trials (RCTs). Further exploration into large randomized controlled trials is needed to fully inform patients and physicians on the utility of these supplements in neuropathic pain. In this review, we explore the basis behind using several nutritional supplements commonly used by patients with neuropathic pain seen in rheumatology clinics.https://www.mdpi.com/2227-9059/9/6/674neuropathic painsupplementszincmagnesiumvitamin Bvitamin D |
| spellingShingle | Khaled M. Abdelrahman Kevin V. Hackshaw Nutritional Supplements for the Treatment of Neuropathic Pain Biomedicines neuropathic pain supplements zinc magnesium vitamin B vitamin D |
| title | Nutritional Supplements for the Treatment of Neuropathic Pain |
| title_full | Nutritional Supplements for the Treatment of Neuropathic Pain |
| title_fullStr | Nutritional Supplements for the Treatment of Neuropathic Pain |
| title_full_unstemmed | Nutritional Supplements for the Treatment of Neuropathic Pain |
| title_short | Nutritional Supplements for the Treatment of Neuropathic Pain |
| title_sort | nutritional supplements for the treatment of neuropathic pain |
| topic | neuropathic pain supplements zinc magnesium vitamin B vitamin D |
| url | https://www.mdpi.com/2227-9059/9/6/674 |
| work_keys_str_mv | AT khaledmabdelrahman nutritionalsupplementsforthetreatmentofneuropathicpain AT kevinvhackshaw nutritionalsupplementsforthetreatmentofneuropathicpain |