C5a/C5aR1 mediates the IMQ-induced psoriatic skin inflammation via promoting IL-17A expression by γδ T cells in mice

C5a/C5aR1 mediates the IMQ-induced psoriatic skin inflammation via promoting IL-17A expression by γδ T cells in mice

Objective To explore the effects and underlying mechanism of C5a/C5aR1 pathway in mediating imiquimod (IMQ)-induced psoriatic skin inflammation by increasing IL-17A expression in γδ T cells. Methods C5aR1+/+ and C5aR1-/- mice were treated with IMQ or control Vasline cream for 6 consecutive days. The...

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Bibliographic Details
Main Author:	ZHENG Quan-you, LIANG Shen-ju,SHU Yong, ZHOU Shan, ZHONG Yu, SHENG Fen, TANG Ming-jun
Format:	Article
Language:	zho
Published:	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2022-09-01
Series:	Jichu yixue yu linchuang
Subjects:	psoriasis\| c5a/c5ar1 pathway\| interleukin-17a(il-17a)\| γδ t cells
Online Access:	http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-42-9-1325.pdf

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