Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study
Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson’s Disease (PD) remains limited. Objective: We examined the association between long-term exposure to amb...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022005943 |
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| author | Thomas Cole-Hunter Jiawei Zhang Rina So Evangelia Samoli Shuo Liu Jie Chen Maciej Strak Kathrin Wolf Gudrun Weinmayr Sophia Rodopolou Elizabeth Remfry Kees de Hoogh Tom Bellander Jørgen Brandt Hans Concin Emanuel Zitt Daniela Fecht Francesco Forastiere John Gulliver Barbara Hoffmann Ulla A. Hvidtfeldt Karl-Heinz Jöckel Laust H. Mortensen Matthias Ketzel Diego Yacamán Méndez Karin Leander Petter Ljungman Elodie Faure Pei-Chen Lee Alexis Elbaz Patrik K.E. Magnusson Gabriele Nagel Göran Pershagen Annette Peters Debora Rizzuto Roel C.H. Vermeulen Sara Schramm Massimo Stafoggia Klea Katsouyanni Bert Brunekreef Gerard Hoek Youn-Hee Lim Zorana J. Andersen |
| author_facet | Thomas Cole-Hunter Jiawei Zhang Rina So Evangelia Samoli Shuo Liu Jie Chen Maciej Strak Kathrin Wolf Gudrun Weinmayr Sophia Rodopolou Elizabeth Remfry Kees de Hoogh Tom Bellander Jørgen Brandt Hans Concin Emanuel Zitt Daniela Fecht Francesco Forastiere John Gulliver Barbara Hoffmann Ulla A. Hvidtfeldt Karl-Heinz Jöckel Laust H. Mortensen Matthias Ketzel Diego Yacamán Méndez Karin Leander Petter Ljungman Elodie Faure Pei-Chen Lee Alexis Elbaz Patrik K.E. Magnusson Gabriele Nagel Göran Pershagen Annette Peters Debora Rizzuto Roel C.H. Vermeulen Sara Schramm Massimo Stafoggia Klea Katsouyanni Bert Brunekreef Gerard Hoek Youn-Hee Lim Zorana J. Andersen |
| author_sort | Thomas Cole-Hunter |
| collection | DOAJ |
| description | Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson’s Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01–1.55), NO2 (1.13; 0.95–1.34 per 10 µg/m3), and BC (1.12; 0.94–1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58–0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5. Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality. |
| first_indexed | 2024-04-10T21:41:15Z |
| format | Article |
| id | doaj.art-4559348bdc9c4dada13b31f1d7959b2b |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-10T21:41:15Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-4559348bdc9c4dada13b31f1d7959b2b2023-01-19T04:16:09ZengElsevierEnvironment International0160-41202023-01-01171107667Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE studyThomas Cole-Hunter0Jiawei Zhang1Rina So2Evangelia Samoli3Shuo Liu4Jie Chen5Maciej Strak6Kathrin Wolf7Gudrun Weinmayr8Sophia Rodopolou9Elizabeth Remfry10Kees de Hoogh11Tom Bellander12Jørgen Brandt13Hans Concin14Emanuel Zitt15Daniela Fecht16Francesco Forastiere17John Gulliver18Barbara Hoffmann19Ulla A. Hvidtfeldt20Karl-Heinz Jöckel21Laust H. Mortensen22Matthias Ketzel23Diego Yacamán Méndez24Karin Leander25Petter Ljungman26Elodie Faure27Pei-Chen Lee28Alexis Elbaz29Patrik K.E. Magnusson30Gabriele Nagel31Göran Pershagen32Annette Peters33Debora Rizzuto34Roel C.H. Vermeulen35Sara Schramm36Massimo Stafoggia37Klea Katsouyanni38Bert Brunekreef39Gerard Hoek40Youn-Hee Lim41Zorana J. Andersen42Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, GreeceSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the NetherlandsInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, GermanyInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, GreeceWolfson Institute of Population Health, Queen Mary University of London, United KingdomSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, SwitzerlandInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, SwedenDepartment of Environmental Science, Aarhus University, Roskilde, Denmark; iClimate, interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, DenmarkAgency for Preventive and Social Medicine (aks), Bregenz, AustriaAgency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, AustriaMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United KingdomDepartment of Epidemiology, Lazio Region Health Service / ASL Roma 1, Rome, Italy; MRC Centre for Environment and Health, Environmental Research Group, School of Public Health, Imperial College London, London, United KingdomMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, United KingdomInstitute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, GermanyDanish Cancer Society Research Center, Copenhagen, DenmarkInstitute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, GermanySection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Statistics Denmark, Copenhagen, DenmarkDepartment of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford GU2 7XH, United KingdomDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Danderyd University Hospital, Stockholm, SwedenUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, 94805 Villejuif, FranceUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, 94805 Villejuif, France; Department of Public Health, National Cheng Kung University, Tainan, TaiwanUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, “Exposome and Heredity” team, CESP UMR1018, 94805 Villejuif, FranceDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, SwedenInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany; Ludwig Maximilians Universität München, München, GermanyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, SwedenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsInstitute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, GermanyInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service / ASL Roma 1, Rome, ItalyDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; MRC Centre for Environment and Health, Environmental Research Group, School of Public Health, Imperial College London, London, United KingdomInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Corresponding author.Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson’s Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01–1.55), NO2 (1.13; 0.95–1.34 per 10 µg/m3), and BC (1.12; 0.94–1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58–0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5. Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.http://www.sciencedirect.com/science/article/pii/S0160412022005943Air pollutionAdultsParkinson’s DiseaseLong-term exposureLow-level exposurePooled-cohort study |
| spellingShingle | Thomas Cole-Hunter Jiawei Zhang Rina So Evangelia Samoli Shuo Liu Jie Chen Maciej Strak Kathrin Wolf Gudrun Weinmayr Sophia Rodopolou Elizabeth Remfry Kees de Hoogh Tom Bellander Jørgen Brandt Hans Concin Emanuel Zitt Daniela Fecht Francesco Forastiere John Gulliver Barbara Hoffmann Ulla A. Hvidtfeldt Karl-Heinz Jöckel Laust H. Mortensen Matthias Ketzel Diego Yacamán Méndez Karin Leander Petter Ljungman Elodie Faure Pei-Chen Lee Alexis Elbaz Patrik K.E. Magnusson Gabriele Nagel Göran Pershagen Annette Peters Debora Rizzuto Roel C.H. Vermeulen Sara Schramm Massimo Stafoggia Klea Katsouyanni Bert Brunekreef Gerard Hoek Youn-Hee Lim Zorana J. Andersen Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study Environment International Air pollution Adults Parkinson’s Disease Long-term exposure Low-level exposure Pooled-cohort study |
| title | Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study |
| title_full | Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study |
| title_fullStr | Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study |
| title_full_unstemmed | Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study |
| title_short | Long-term air pollution exposure and Parkinson’s disease mortality in a large pooled European cohort: An ELAPSE study |
| title_sort | long term air pollution exposure and parkinson s disease mortality in a large pooled european cohort an elapse study |
| topic | Air pollution Adults Parkinson’s Disease Long-term exposure Low-level exposure Pooled-cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022005943 |
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