Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries
Ischemia-reperfusion injuries (IRI) are the major causes of liver failure after various types of liver surgeries such as biopsy, transplantation, and tumor surgery. Its pathogenesis is multifactorial and complex that involves ATP depletion, hepatocyte edema, acidosis, oxidative stress, inflammation,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2017-12-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-10293-en.html |
| _version_ | 1797943704207491072 |
|---|---|
| author | Vahid Akbari Kordkheyli Setareh Zarpou Pooneh yazdani Abbas Khonakdar Tarsi |
| author_facet | Vahid Akbari Kordkheyli Setareh Zarpou Pooneh yazdani Abbas Khonakdar Tarsi |
| author_sort | Vahid Akbari Kordkheyli |
| collection | DOAJ |
| description | Ischemia-reperfusion injuries (IRI) are the major causes of liver failure after various types of liver surgeries such as biopsy, transplantation, and tumor surgery. Its pathogenesis is multifactorial and complex that involves ATP depletion, hepatocyte edema, acidosis, oxidative stress, inflammation, and microcirculation defect which can eventually progress to liver cell death, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome, and even acute graft rejection. There are much evidences that suggest applying anti-inflammatory drugs could be a proper strategy to decrease IRI. Dexamethasone is a highly potent synthetic corticosteroid that its beneficial effects on various tissues in IRI are well documented. It also suppresses inflammation and immune response in different pathologic conditions. Its functional mechanism is different in various types of cells and involves: inactivation of NF-κB and AP-1, inhibition of releasing PLA2 and arachidonic acid, and induction of ERK1/2 and SGK-1. By these processes dexamethasone is able to prevent cytokine overproduction and leukocyte activation, recruitment and infiltration. In this review, we aimed to explain the protective effects of dexamethasone on liver ischemia-reperfusion injuries. |
| first_indexed | 2024-04-10T20:28:24Z |
| format | Article |
| id | doaj.art-455b3fe15d2c4c678d10e8e13e465ed8 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:28:24Z |
| publishDate | 2017-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-455b3fe15d2c4c678d10e8e13e465ed82023-01-25T07:43:27ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792017-12-0127155196209Effects of Dexamethasone on Hepatic Ischemia-reperfusion InjuriesVahid Akbari Kordkheyli0Setareh Zarpou1Pooneh yazdani2Abbas Khonakdar Tarsi3 MSc Student in Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran MSc Student in Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Ischemia-reperfusion injuries (IRI) are the major causes of liver failure after various types of liver surgeries such as biopsy, transplantation, and tumor surgery. Its pathogenesis is multifactorial and complex that involves ATP depletion, hepatocyte edema, acidosis, oxidative stress, inflammation, and microcirculation defect which can eventually progress to liver cell death, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome, and even acute graft rejection. There are much evidences that suggest applying anti-inflammatory drugs could be a proper strategy to decrease IRI. Dexamethasone is a highly potent synthetic corticosteroid that its beneficial effects on various tissues in IRI are well documented. It also suppresses inflammation and immune response in different pathologic conditions. Its functional mechanism is different in various types of cells and involves: inactivation of NF-κB and AP-1, inhibition of releasing PLA2 and arachidonic acid, and induction of ERK1/2 and SGK-1. By these processes dexamethasone is able to prevent cytokine overproduction and leukocyte activation, recruitment and infiltration. In this review, we aimed to explain the protective effects of dexamethasone on liver ischemia-reperfusion injuries.http://jmums.mazums.ac.ir/article-1-10293-en.htmlischemiareperfusiondexamethasoneinflammation |
| spellingShingle | Vahid Akbari Kordkheyli Setareh Zarpou Pooneh yazdani Abbas Khonakdar Tarsi Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries Journal of Mazandaran University of Medical Sciences ischemia reperfusion dexamethasone inflammation |
| title | Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries |
| title_full | Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries |
| title_fullStr | Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries |
| title_full_unstemmed | Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries |
| title_short | Effects of Dexamethasone on Hepatic Ischemia-reperfusion Injuries |
| title_sort | effects of dexamethasone on hepatic ischemia reperfusion injuries |
| topic | ischemia reperfusion dexamethasone inflammation |
| url | http://jmums.mazums.ac.ir/article-1-10293-en.html |
| work_keys_str_mv | AT vahidakbarikordkheyli effectsofdexamethasoneonhepaticischemiareperfusioninjuries AT setarehzarpou effectsofdexamethasoneonhepaticischemiareperfusioninjuries AT poonehyazdani effectsofdexamethasoneonhepaticischemiareperfusioninjuries AT abbaskhonakdartarsi effectsofdexamethasoneonhepaticischemiareperfusioninjuries |