Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period
Copeptin (CTproAVP) is a stable by-product of arginine–vasopressin synthesis and reflects its secretion by the pituitary gland, considered as a potential new marker of dehydration. The objective of the study was to investigate CTproAVP measured after the first 48 h of postnatal life in relation to s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/3/443 |
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| author | Anna Jarosz-Lesz Aniceta Brzozowska Iwona Maruniak-Chudek |
| author_facet | Anna Jarosz-Lesz Aniceta Brzozowska Iwona Maruniak-Chudek |
| author_sort | Anna Jarosz-Lesz |
| collection | DOAJ |
| description | Copeptin (CTproAVP) is a stable by-product of arginine–vasopressin synthesis and reflects its secretion by the pituitary gland, considered as a potential new marker of dehydration. The objective of the study was to investigate CTproAVP measured after the first 48 h of postnatal life in relation to serum effective osmolality, urine osmolality, and vessels filling according to the following variables: delivery mode, postnatal weight loss, fluids administered intravenously to the mother, and fluids given orally to the neonate. A prospective observational study was conducted with 200 healthy term infants (53% male) enrolled. Serum CTproAVP concentrations were measured using the ELISA kit; haematocrit, urine osmolality, serum effective osmolality were assessed after 48 h of life. Sonographic measurements of inferior vena cava (IVC) and aorta (Ao) were performed and IVC/Ao ratios were calculated. No correlations were found between CTproAVP concentrations and both serum effective osmolality and urine osmolality. There was also no association between CTproAVP concentrations and vessel filling represented by IVC/Ao index at 48 h of life. |
| first_indexed | 2024-03-09T19:58:51Z |
| format | Article |
| id | doaj.art-455bc378b19d4a56ba57ffcffbae5ad0 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T19:58:51Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-455bc378b19d4a56ba57ffcffbae5ad02023-11-24T00:48:08ZengMDPI AGChildren2227-90672022-03-019344310.3390/children9030443Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation PeriodAnna Jarosz-Lesz0Aniceta Brzozowska1Iwona Maruniak-Chudek2Neonatology Unit, The Guardian Angels Hospital of the Brothers Hospitallers of St. John of God in Katowice, 40-211 Katowice, PolandHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Neonatology and Neonatal Intensive Care, Faculty of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, PolandCopeptin (CTproAVP) is a stable by-product of arginine–vasopressin synthesis and reflects its secretion by the pituitary gland, considered as a potential new marker of dehydration. The objective of the study was to investigate CTproAVP measured after the first 48 h of postnatal life in relation to serum effective osmolality, urine osmolality, and vessels filling according to the following variables: delivery mode, postnatal weight loss, fluids administered intravenously to the mother, and fluids given orally to the neonate. A prospective observational study was conducted with 200 healthy term infants (53% male) enrolled. Serum CTproAVP concentrations were measured using the ELISA kit; haematocrit, urine osmolality, serum effective osmolality were assessed after 48 h of life. Sonographic measurements of inferior vena cava (IVC) and aorta (Ao) were performed and IVC/Ao ratios were calculated. No correlations were found between CTproAVP concentrations and both serum effective osmolality and urine osmolality. There was also no association between CTproAVP concentrations and vessel filling represented by IVC/Ao index at 48 h of life.https://www.mdpi.com/2227-9067/9/3/443copeptinnewbornshydration statuselectrolyte-water homeostasis |
| spellingShingle | Anna Jarosz-Lesz Aniceta Brzozowska Iwona Maruniak-Chudek Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period Children copeptin newborns hydration status electrolyte-water homeostasis |
| title | Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period |
| title_full | Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period |
| title_fullStr | Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period |
| title_full_unstemmed | Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period |
| title_short | Copeptin Concentrations in Plasma of Healthy Neonates in Relation to Water–Electrolyte Homeostasis in the Early Adaptation Period |
| title_sort | copeptin concentrations in plasma of healthy neonates in relation to water electrolyte homeostasis in the early adaptation period |
| topic | copeptin newborns hydration status electrolyte-water homeostasis |
| url | https://www.mdpi.com/2227-9067/9/3/443 |
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