From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia
Abstract Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools. Deoxycytidine kinase is the rate-limiting enzyme of the salvage pathway and it has recently emerged as a target for anti-proliferative...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-38668-2 |