Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum
Two new potentiometric sensors were created for the quantification of bisoprolol fumarate and alverine citrate in bulk pharmaceutical dosage forms and human serum. Bisoprolol and alverine sensors were manufactured by combining potassium tetrakis (p-chlorophenyl) borate ion pairs to serve as electroa...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-05-01
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| Series: | Reviews in Analytical Chemistry |
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| Online Access: | https://doi.org/10.1515/revac-2021-0129 |
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| author | Elgendy Khaled Elmosallamy Mohamed A.F. Soltan Moustafa K. Amin Alaa S. Elshaprawy Dina S. |
| author_facet | Elgendy Khaled Elmosallamy Mohamed A.F. Soltan Moustafa K. Amin Alaa S. Elshaprawy Dina S. |
| author_sort | Elgendy Khaled |
| collection | DOAJ |
| description | Two new potentiometric sensors were created for the quantification of bisoprolol fumarate and alverine citrate in bulk pharmaceutical dosage forms and human serum. Bisoprolol and alverine sensors were manufactured by combining potassium tetrakis (p-chlorophenyl) borate ion pairs to serve as electroactive substances, plasticized poly (vinyl chloride) matrix membranes, and o-nitrophenyl octyl ether. They demonstrated high responses over the concentration ranges of 1.0×10−6 to 1.0×10−2 mol L−1 bisoprolol and alverine with close to Nernstian cationic slopes of 52 and 56 mV decade−1, respectively. The detection limits for bisoprolol and alverine were 2.6×10−6 and 1.75×10−6 mol L−1, respectively. For both medications, the response time was instantaneous (2.0 s). The working pH ranges for bisoprolol and alverine were 4.50–8.50 and 2.00–8.80, respectively. For both sensors, the life cycle was long (3 months). The sensors were used in pharmaceutical dosage types for the assay of bisoprolol and alverine, recording average recoveries of 99.40% and 99.98% respectively and were also successfully used for estimating the two drugs in human serum with an average recovery of 99.60% for both drugs. For all multiple staged interfering materials, the reported latest potentiometric sensor methods displayed high selectivity. The current sensor obtained a high percentage recovery and an excellent relative standard deviation compared with those obtained from previously published methods. |
| first_indexed | 2024-12-19T17:54:15Z |
| format | Article |
| id | doaj.art-455cf235f67d463e87a5b32f0c2faba7 |
| institution | Directory Open Access Journal |
| issn | 0793-0135 2191-0189 |
| language | English |
| last_indexed | 2024-12-19T17:54:15Z |
| publishDate | 2021-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews in Analytical Chemistry |
| spelling | doaj.art-455cf235f67d463e87a5b32f0c2faba72022-12-21T20:11:50ZengDe GruyterReviews in Analytical Chemistry0793-01352191-01892021-05-0140112713510.1515/revac-2021-0129Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serumElgendy Khaled0Elmosallamy Mohamed A.F.1Soltan Moustafa K.2Amin Alaa S.3Elshaprawy Dina S.4Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, EgyptFaculty of Pharmacy, Zagazig University, Zagazig, Egypt, Oman College of Health Sciences, OmanDepartment of Chemistry, Faculty of Science, Benha University, Benha, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, EgyptTwo new potentiometric sensors were created for the quantification of bisoprolol fumarate and alverine citrate in bulk pharmaceutical dosage forms and human serum. Bisoprolol and alverine sensors were manufactured by combining potassium tetrakis (p-chlorophenyl) borate ion pairs to serve as electroactive substances, plasticized poly (vinyl chloride) matrix membranes, and o-nitrophenyl octyl ether. They demonstrated high responses over the concentration ranges of 1.0×10−6 to 1.0×10−2 mol L−1 bisoprolol and alverine with close to Nernstian cationic slopes of 52 and 56 mV decade−1, respectively. The detection limits for bisoprolol and alverine were 2.6×10−6 and 1.75×10−6 mol L−1, respectively. For both medications, the response time was instantaneous (2.0 s). The working pH ranges for bisoprolol and alverine were 4.50–8.50 and 2.00–8.80, respectively. For both sensors, the life cycle was long (3 months). The sensors were used in pharmaceutical dosage types for the assay of bisoprolol and alverine, recording average recoveries of 99.40% and 99.98% respectively and were also successfully used for estimating the two drugs in human serum with an average recovery of 99.60% for both drugs. For all multiple staged interfering materials, the reported latest potentiometric sensor methods displayed high selectivity. The current sensor obtained a high percentage recovery and an excellent relative standard deviation compared with those obtained from previously published methods.https://doi.org/10.1515/revac-2021-0129bisoprolol fumaratealverine citratepotassium tetrakis (p-chlorophenyl) boratepotentiometric sensorspharmaceutical preparationshuman serum |
| spellingShingle | Elgendy Khaled Elmosallamy Mohamed A.F. Soltan Moustafa K. Amin Alaa S. Elshaprawy Dina S. Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum Reviews in Analytical Chemistry bisoprolol fumarate alverine citrate potassium tetrakis (p-chlorophenyl) borate potentiometric sensors pharmaceutical preparations human serum |
| title | Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum |
| title_full | Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum |
| title_fullStr | Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum |
| title_full_unstemmed | Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum |
| title_short | Novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum |
| title_sort | novel potentiometric methods for the estimation of bisoprolol and alverine in pharmaceutical forms and human serum |
| topic | bisoprolol fumarate alverine citrate potassium tetrakis (p-chlorophenyl) borate potentiometric sensors pharmaceutical preparations human serum |
| url | https://doi.org/10.1515/revac-2021-0129 |
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