Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
Abstract Loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a biological marker of central serotonergic activity related to suicides. This study’s objective was to analyze the difference in LDAEP between depressed patients with suicide attempts (SA) and suicidal ideation...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-86602-7 |
| _version_ | 1818749652325892096 |
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| author | Ji Sun Kim Sungkean Kim Ho-Sung Lee Young Joon Kwon Hwa Young Lee Se-Hoon Shim |
| author_facet | Ji Sun Kim Sungkean Kim Ho-Sung Lee Young Joon Kwon Hwa Young Lee Se-Hoon Shim |
| author_sort | Ji Sun Kim |
| collection | DOAJ |
| description | Abstract Loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a biological marker of central serotonergic activity related to suicides. This study’s objective was to analyze the difference in LDAEP between depressed patients with suicide attempts (SA) and suicidal ideation (SI). It included 130 participants (45 depressed patients with SA, 49 depressed patients with SI, and 36 healthy controls) aged > 18 years who exhibited LDAEP during electroencephalography. Psychological characteristics and event-related potentials of the three groups were compared. There was no significant difference in LDAEP between major depressive disorder (MDD) patients with SA and SI (p = 0.59). MDD patients with SI, who attempted suicide had significantly lower LDAEP than healthy controls (p = 0.01 and p = 0.01, respectively). However, the significance disappeared when psychological characteristics were controlled. Our results suggest that LDAEP might not be possible biomarkers for suicidal behaviors in patients with MDD. Further studies to assess the biological basis of suicide and identify the underlying dimensions that mediate the relationship between the biological basis and suicidal behaviors will be needed. |
| first_indexed | 2024-12-18T04:07:11Z |
| format | Article |
| id | doaj.art-455d8457f8074bc091aaa5c071b4ff3d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:07:11Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-455d8457f8074bc091aaa5c071b4ff3d2022-12-21T21:21:34ZengNature PortfolioScientific Reports2045-23222021-03-0111111010.1038/s41598-021-86602-7Auditory evoked potentials and suicidal behaviors in patients with major depressive disordersJi Sun Kim0Sungkean Kim1Ho-Sung Lee2Young Joon Kwon3Hwa Young Lee4Se-Hoon Shim5Department of Psychiatry, College of Medicine, Soonchunhyang University Cheonan HospitalDepartment of Human-Computer Interaction, Hanyang UniversityDepartment of Pulmonology and Allergy, Cheonan Hospital, Soonchunhyang UniversityDepartment of Psychiatry, College of Medicine, Soonchunhyang University Cheonan HospitalDepartment of Psychiatry, College of Medicine, Soonchunhyang University Cheonan HospitalDepartment of Psychiatry, College of Medicine, Soonchunhyang University Cheonan HospitalAbstract Loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a biological marker of central serotonergic activity related to suicides. This study’s objective was to analyze the difference in LDAEP between depressed patients with suicide attempts (SA) and suicidal ideation (SI). It included 130 participants (45 depressed patients with SA, 49 depressed patients with SI, and 36 healthy controls) aged > 18 years who exhibited LDAEP during electroencephalography. Psychological characteristics and event-related potentials of the three groups were compared. There was no significant difference in LDAEP between major depressive disorder (MDD) patients with SA and SI (p = 0.59). MDD patients with SI, who attempted suicide had significantly lower LDAEP than healthy controls (p = 0.01 and p = 0.01, respectively). However, the significance disappeared when psychological characteristics were controlled. Our results suggest that LDAEP might not be possible biomarkers for suicidal behaviors in patients with MDD. Further studies to assess the biological basis of suicide and identify the underlying dimensions that mediate the relationship between the biological basis and suicidal behaviors will be needed.https://doi.org/10.1038/s41598-021-86602-7 |
| spellingShingle | Ji Sun Kim Sungkean Kim Ho-Sung Lee Young Joon Kwon Hwa Young Lee Se-Hoon Shim Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders Scientific Reports |
| title | Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders |
| title_full | Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders |
| title_fullStr | Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders |
| title_full_unstemmed | Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders |
| title_short | Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders |
| title_sort | auditory evoked potentials and suicidal behaviors in patients with major depressive disorders |
| url | https://doi.org/10.1038/s41598-021-86602-7 |
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