Comparative Antitumor Effect of Preventive versus Therapeutic Vaccines Employing B16 Melanoma Cells Genetically Modified to Express GM-CSF and B7.2 in a Murine Model

Comparative Antitumor Effect of Preventive versus Therapeutic Vaccines Employing B16 Melanoma Cells Genetically Modified to Express GM-CSF and B7.2 in a Murine Model

Cancer vaccines have always been a subject of gene therapy research. One of the most successful approaches has been working with genetically modified tumor cells. In this study, we describe our approach to achieving an immune response against a murine melanoma model, employing B16 tumor cells expres...

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Bibliographic Details
Main Authors: Salvador F. Aliño, Maria Sánchez, Rosa Algás, Rafael Botella, Luis Sendra, Antonio Miguel, María José Herrero
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Toxins
Subjects:
cancer vaccines
gene therapy
non-viral
GM-CSF
B7.2
Online Access:http://www.mdpi.com/2072-6651/4/11/1058

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