Constraints and frustration in the clathrin-dependent endocytosis pathway
Clathrin-dependent endocytosis is the major pathway for the entry of most surface receptors and their ligands. It is controlled by clathrin-coated structures that are endowed with the ability to cluster receptors and locally bend the plasma membrane, leading to the formation of receptor-containing v...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Académie des sciences
2022-09-01
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| Series: | Comptes Rendus Biologies |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.88/ |
| _version_ | 1827785077050834944 |
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| author | Bruna-Gauchoux, Julie Montagnac, Guillaume |
| author_facet | Bruna-Gauchoux, Julie Montagnac, Guillaume |
| author_sort | Bruna-Gauchoux, Julie |
| collection | DOAJ |
| description | Clathrin-dependent endocytosis is the major pathway for the entry of most surface receptors and their ligands. It is controlled by clathrin-coated structures that are endowed with the ability to cluster receptors and locally bend the plasma membrane, leading to the formation of receptor-containing vesicles budding into the cytoplasm. This canonical role of clathrin-coated structures has been repeatedly demonstrated to play a fundamental role in a wide range of aspects of cell physiology. However, it is now clearly established that the ability of clathrin-coated structures to bend the membrane can be disrupted. In addition to chemical or genetic alterations, many environmental conditions can physically prevent or slow membrane deformation and/or budding of clathrin-coated structures. The resulting frustrated endocytosis is not only a passive consequence but serves very specific and important cellular functions. Here we provide a historical perspective as well as a definition of frustrated endocytosis in the clathrin pathway before describing its causes and many functional consequences. |
| first_indexed | 2024-03-11T16:13:04Z |
| format | Article |
| id | doaj.art-455fdfcb8e7f48cca4e395a322c6497f |
| institution | Directory Open Access Journal |
| issn | 1768-3238 |
| language | English |
| last_indexed | 2024-03-11T16:13:04Z |
| publishDate | 2022-09-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj.art-455fdfcb8e7f48cca4e395a322c6497f2023-10-24T14:25:24ZengAcadémie des sciencesComptes Rendus Biologies1768-32382022-09-013452435610.5802/crbiol.8810.5802/crbiol.88Constraints and frustration in the clathrin-dependent endocytosis pathwayBruna-Gauchoux, Julie0Montagnac, Guillaume1Inserm U1279, Gustave Roussy Institute, Université Paris-Saclay, Villejuif, FranceInserm U1279, Gustave Roussy Institute, Université Paris-Saclay, Villejuif, FranceClathrin-dependent endocytosis is the major pathway for the entry of most surface receptors and their ligands. It is controlled by clathrin-coated structures that are endowed with the ability to cluster receptors and locally bend the plasma membrane, leading to the formation of receptor-containing vesicles budding into the cytoplasm. This canonical role of clathrin-coated structures has been repeatedly demonstrated to play a fundamental role in a wide range of aspects of cell physiology. However, it is now clearly established that the ability of clathrin-coated structures to bend the membrane can be disrupted. In addition to chemical or genetic alterations, many environmental conditions can physically prevent or slow membrane deformation and/or budding of clathrin-coated structures. The resulting frustrated endocytosis is not only a passive consequence but serves very specific and important cellular functions. Here we provide a historical perspective as well as a definition of frustrated endocytosis in the clathrin pathway before describing its causes and many functional consequences.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.88/EndocytosisClathrinMigrationMechanotransductionSignaling |
| spellingShingle | Bruna-Gauchoux, Julie Montagnac, Guillaume Constraints and frustration in the clathrin-dependent endocytosis pathway Comptes Rendus Biologies Endocytosis Clathrin Migration Mechanotransduction Signaling |
| title | Constraints and frustration in the clathrin-dependent endocytosis pathway |
| title_full | Constraints and frustration in the clathrin-dependent endocytosis pathway |
| title_fullStr | Constraints and frustration in the clathrin-dependent endocytosis pathway |
| title_full_unstemmed | Constraints and frustration in the clathrin-dependent endocytosis pathway |
| title_short | Constraints and frustration in the clathrin-dependent endocytosis pathway |
| title_sort | constraints and frustration in the clathrin dependent endocytosis pathway |
| topic | Endocytosis Clathrin Migration Mechanotransduction Signaling |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.88/ |
| work_keys_str_mv | AT brunagauchouxjulie constraintsandfrustrationintheclathrindependentendocytosispathway AT montagnacguillaume constraintsandfrustrationintheclathrindependentendocytosispathway |