Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry
The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/8/1054 |
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| author | Francesca Ambrogio Gerardo Cazzato Caterina Foti Mauro Grandolfo Gisella Biagina Mennuni Gino Antonio Vena Nicoletta Cassano Teresa Lettini Cosimo Castronovi Vito Ingordo Paolo Romita Raffaele Filotico |
| author_facet | Francesca Ambrogio Gerardo Cazzato Caterina Foti Mauro Grandolfo Gisella Biagina Mennuni Gino Antonio Vena Nicoletta Cassano Teresa Lettini Cosimo Castronovi Vito Ingordo Paolo Romita Raffaele Filotico |
| author_sort | Francesca Ambrogio |
| collection | DOAJ |
| description | The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old man who presented with a 4-week history of non-pruritic generalised macules, papules, nodules and plaques. Histopathologically, there was a dense perivascular and periadnexal lympho-histiocytic dermal infiltrate with non-palisading and non-caseifying epithelioid granulomas and abundant plasma cells. The diagnosis of syphilis was confirmed by serology and immunohistochemical detection of <i>Treponema pallidum</i> in the biopsy specimen. A brief overview of the diagnostic role of immunohistochemistry is also provided, with particular emphasis on reported cases of granulomatous secondary syphilis. |
| first_indexed | 2024-03-10T23:39:25Z |
| format | Article |
| id | doaj.art-45605f98907646658e40b1085c5682dd |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T23:39:25Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-45605f98907646658e40b1085c5682dd2023-11-19T02:32:56ZengMDPI AGPathogens2076-08172023-08-01128105410.3390/pathogens12081054Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of ImmunohistochemistryFrancesca Ambrogio0Gerardo Cazzato1Caterina Foti2Mauro Grandolfo3Gisella Biagina Mennuni4Gino Antonio Vena5Nicoletta Cassano6Teresa Lettini7Cosimo Castronovi8Vito Ingordo9Paolo Romita10Raffaele Filotico11Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyDermatology and Venereology Private Practice, 76121 Barletta, ItalyDermatology and Venereology Private Practice, 76121 Barletta, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyOutpatients’ Department of Dermatology, District n.6, Local Health Centre Taranto, 74121 Taranto, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyThe diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old man who presented with a 4-week history of non-pruritic generalised macules, papules, nodules and plaques. Histopathologically, there was a dense perivascular and periadnexal lympho-histiocytic dermal infiltrate with non-palisading and non-caseifying epithelioid granulomas and abundant plasma cells. The diagnosis of syphilis was confirmed by serology and immunohistochemical detection of <i>Treponema pallidum</i> in the biopsy specimen. A brief overview of the diagnostic role of immunohistochemistry is also provided, with particular emphasis on reported cases of granulomatous secondary syphilis.https://www.mdpi.com/2076-0817/12/8/1054immunohistochemistrygranulomagranulomatous histological patternsecondary syphilis<i>Treponema pallidum</i> |
| spellingShingle | Francesca Ambrogio Gerardo Cazzato Caterina Foti Mauro Grandolfo Gisella Biagina Mennuni Gino Antonio Vena Nicoletta Cassano Teresa Lettini Cosimo Castronovi Vito Ingordo Paolo Romita Raffaele Filotico Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry Pathogens immunohistochemistry granuloma granulomatous histological pattern secondary syphilis <i>Treponema pallidum</i> |
| title | Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry |
| title_full | Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry |
| title_fullStr | Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry |
| title_full_unstemmed | Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry |
| title_short | Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry |
| title_sort | granulomatous secondary syphilis a case report with a brief overview of the diagnostic role of immunohistochemistry |
| topic | immunohistochemistry granuloma granulomatous histological pattern secondary syphilis <i>Treponema pallidum</i> |
| url | https://www.mdpi.com/2076-0817/12/8/1054 |
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