Quantification of macular perfusion in healthy children using optical coherence tomography angiography
Abstract Background This study aimed at defining the variance of vessel density (VD) characteristics in the macula of children with normal eyes. Methods This was a cross-sectional study in which subjects with normal eyes aged 3–18 years were enrolled. The macula was scanned by optical coherence tomo...
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| Format: | Article |
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BMC
2021-10-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | https://doi.org/10.1186/s40942-021-00328-2 |
| _version_ | 1818717197597409280 |
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| author | Fariba Ghassemi Vahid Hatami Farhad Salari Fatemeh Bazvand Hadi Shamouli Masoumeh Mohebbi Siamak Sabour |
| author_facet | Fariba Ghassemi Vahid Hatami Farhad Salari Fatemeh Bazvand Hadi Shamouli Masoumeh Mohebbi Siamak Sabour |
| author_sort | Fariba Ghassemi |
| collection | DOAJ |
| description | Abstract Background This study aimed at defining the variance of vessel density (VD) characteristics in the macula of children with normal eyes. Methods This was a cross-sectional study in which subjects with normal eyes aged 3–18 years were enrolled. The macula was scanned by optical coherence tomography angiography (OCTA). Four age groups as under 7 years, 7–10 years, 11–14 years and more than 14 years of age were defined. The influences of age, gender, and body mass index on VD were analyzed. Results A total of 108 normal eyes from 54 participants with a mean age of 10.9 years were enrolled in the study. At the superficial and deep retina capillary plexus (SCP and DCP) and choriocapillaris (CC), respectively, the mean VD of the fovea was 20.10%, 36.99%, and 75.67%; at parafovea, these measurements were 53.12%, 55.81%, and 69.76%; and at perifovea, these measures were 51.38%, 52.46%, and 73.47%. The median foveal avascular zone (FAZ) was 0.30 mm2. No significant differences between superior-hemi VD and inferior-hemi VD were found in the studied plexuses. The VD at parafovea and perifovea CC differed significantly between groups. There was no variation in VD of macular retina and CC between eyes or sex. FAZ areas were different between genders. Conclusions No difference between eyes and genders in the retina and CC VD of macular area was noted. FAZ area was larger in male. Even though this is not a longitudinal study, it may provide us with hints about macular vascular development during puberty and clinical implications of OCTA in children. |
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| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-17T19:31:20Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
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| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-45607a2619e84f1cb4bd82c17448250d2022-12-21T21:35:14ZengBMCInternational Journal of Retina and Vitreous2056-99202021-10-01711910.1186/s40942-021-00328-2Quantification of macular perfusion in healthy children using optical coherence tomography angiographyFariba Ghassemi0Vahid Hatami1Farhad Salari2Fatemeh Bazvand3Hadi Shamouli4Masoumeh Mohebbi5Siamak Sabour6Eye Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesEye Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesEye Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesEye Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesEye Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesEye Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesDepartment of Clinical Epidemiology, School of Health and Safety, Safety Promotion and Injury Prevention Research CentreAbstract Background This study aimed at defining the variance of vessel density (VD) characteristics in the macula of children with normal eyes. Methods This was a cross-sectional study in which subjects with normal eyes aged 3–18 years were enrolled. The macula was scanned by optical coherence tomography angiography (OCTA). Four age groups as under 7 years, 7–10 years, 11–14 years and more than 14 years of age were defined. The influences of age, gender, and body mass index on VD were analyzed. Results A total of 108 normal eyes from 54 participants with a mean age of 10.9 years were enrolled in the study. At the superficial and deep retina capillary plexus (SCP and DCP) and choriocapillaris (CC), respectively, the mean VD of the fovea was 20.10%, 36.99%, and 75.67%; at parafovea, these measurements were 53.12%, 55.81%, and 69.76%; and at perifovea, these measures were 51.38%, 52.46%, and 73.47%. The median foveal avascular zone (FAZ) was 0.30 mm2. No significant differences between superior-hemi VD and inferior-hemi VD were found in the studied plexuses. The VD at parafovea and perifovea CC differed significantly between groups. There was no variation in VD of macular retina and CC between eyes or sex. FAZ areas were different between genders. Conclusions No difference between eyes and genders in the retina and CC VD of macular area was noted. FAZ area was larger in male. Even though this is not a longitudinal study, it may provide us with hints about macular vascular development during puberty and clinical implications of OCTA in children.https://doi.org/10.1186/s40942-021-00328-2ChoriocapillarisDeep capillary plexusFoveal avascular zoneOptical coherence tomographySuperficial capillary plexusVascular density |
| spellingShingle | Fariba Ghassemi Vahid Hatami Farhad Salari Fatemeh Bazvand Hadi Shamouli Masoumeh Mohebbi Siamak Sabour Quantification of macular perfusion in healthy children using optical coherence tomography angiography International Journal of Retina and Vitreous Choriocapillaris Deep capillary plexus Foveal avascular zone Optical coherence tomography Superficial capillary plexus Vascular density |
| title | Quantification of macular perfusion in healthy children using optical coherence tomography angiography |
| title_full | Quantification of macular perfusion in healthy children using optical coherence tomography angiography |
| title_fullStr | Quantification of macular perfusion in healthy children using optical coherence tomography angiography |
| title_full_unstemmed | Quantification of macular perfusion in healthy children using optical coherence tomography angiography |
| title_short | Quantification of macular perfusion in healthy children using optical coherence tomography angiography |
| title_sort | quantification of macular perfusion in healthy children using optical coherence tomography angiography |
| topic | Choriocapillaris Deep capillary plexus Foveal avascular zone Optical coherence tomography Superficial capillary plexus Vascular density |
| url | https://doi.org/10.1186/s40942-021-00328-2 |
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