Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit
Aim: We assessed late onset sepsis (LOS) rates of neonates in a neonatal intensive care unit (NICU) before and after implementing an evidence-based bundle to prevent these infections in a country with poor resources. Methods: We evaluate trends of LOS between October 2010 and August 2012 in a large...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867014002049 |
| _version_ | 1818204912740204544 |
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| author | Daiane Silva Resende Anna Laura Gil Peppe Heloisio dos Reis Vânia Olivetti Steffen Abdallah Rosineide Marques Ribas Paulo Pinto Gontijo Filho |
| author_facet | Daiane Silva Resende Anna Laura Gil Peppe Heloisio dos Reis Vânia Olivetti Steffen Abdallah Rosineide Marques Ribas Paulo Pinto Gontijo Filho |
| author_sort | Daiane Silva Resende |
| collection | DOAJ |
| description | Aim: We assessed late onset sepsis (LOS) rates of neonates in a neonatal intensive care unit (NICU) before and after implementing an evidence-based bundle to prevent these infections in a country with poor resources. Methods: We evaluate trends of LOS between October 2010 and August 2012 in a large tertiary hospital in Brazil. We designed a protocol based of CDC guidelines for insertion of maintenance of central venous catheter targeted to reduction of bloodstream infections. During this period two major events occurred: a great increase of LOS rates in January months and relocation of the unit to a provisory place. Additionally we evaluated the risk factors and etiology of these infections. Results: A total of 112 (20.3%) cases defined as LOS were found. The overall incidence rate of LOS in the study was 16.1/1000 patient/days and 23.0/1000 CVC-days. Our monthly rates data of LOS/1000 patient-day reveal fluctuations over the studied period, with incidence rates of these infections in staff vacation period (January 2011 and 2012) significantly higher (59.6/1000 patients-days) than compared with the other months rates (16.6/1000 patients-days) (IRR = 3.59; p < 0.001). As opposite, the incidence rates of LOS during relocation period was lower (10.3/1000 patients-days) when compared with baseline period 26.7/1000 patients-days (IRR = 2.59; p = 0.007). After the intervention period, these rates decreased in the post intervention period, when compared with preintervention 14.7/1000 patients-days and 23.4/1000 patients-days, respectively (IRR = 1.59; p = 0.04). Conclusion: Through simple infection control measures, LOS can be successfully controlled especially in NICUs of limited resources countries such as ours. Keywords: Late onset sepsis, Bundle, Neonates |
| first_indexed | 2024-12-12T03:48:47Z |
| format | Article |
| id | doaj.art-4561b4239ebb43ccad9d2aaccf31e00d |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-12T03:48:47Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-4561b4239ebb43ccad9d2aaccf31e00d2022-12-22T00:39:27ZengElsevierBrazilian Journal of Infectious Diseases1413-86702015-01-011915257S1413-86702015000100052Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unitDaiane Silva Resende0Anna Laura Gil Peppe1Heloisio dos Reis2Vânia Olivetti Steffen Abdallah3Rosineide Marques Ribas4Paulo Pinto Gontijo Filho5Microbiology Laboratory, Biomedical Science Institute, Uberlândia Federal University, Uberlândia, MG, Brazil; Corresponding author at: Uberlândia Federal University, Pará Avenue, 1720 Umuarama, Uberlândia, MG, Brazil.Faculty of Medicine, Uberlândia University Hospital, Uberlândia Federal University, Uberlândia, MG, BrazilNeonatology Department, Uberlândia University Hospital, Uberlândia Federal University, Uberlândia, MG, BrazilNeonatology Department, Uberlândia University Hospital, Uberlândia Federal University, Uberlândia, MG, BrazilMicrobiology Laboratory, Biomedical Science Institute, Uberlândia Federal University, Uberlândia, MG, BrazilMicrobiology Laboratory, Biomedical Science Institute, Uberlândia Federal University, Uberlândia, MG, BrazilAim: We assessed late onset sepsis (LOS) rates of neonates in a neonatal intensive care unit (NICU) before and after implementing an evidence-based bundle to prevent these infections in a country with poor resources. Methods: We evaluate trends of LOS between October 2010 and August 2012 in a large tertiary hospital in Brazil. We designed a protocol based of CDC guidelines for insertion of maintenance of central venous catheter targeted to reduction of bloodstream infections. During this period two major events occurred: a great increase of LOS rates in January months and relocation of the unit to a provisory place. Additionally we evaluated the risk factors and etiology of these infections. Results: A total of 112 (20.3%) cases defined as LOS were found. The overall incidence rate of LOS in the study was 16.1/1000 patient/days and 23.0/1000 CVC-days. Our monthly rates data of LOS/1000 patient-day reveal fluctuations over the studied period, with incidence rates of these infections in staff vacation period (January 2011 and 2012) significantly higher (59.6/1000 patients-days) than compared with the other months rates (16.6/1000 patients-days) (IRR = 3.59; p < 0.001). As opposite, the incidence rates of LOS during relocation period was lower (10.3/1000 patients-days) when compared with baseline period 26.7/1000 patients-days (IRR = 2.59; p = 0.007). After the intervention period, these rates decreased in the post intervention period, when compared with preintervention 14.7/1000 patients-days and 23.4/1000 patients-days, respectively (IRR = 1.59; p = 0.04). Conclusion: Through simple infection control measures, LOS can be successfully controlled especially in NICUs of limited resources countries such as ours. Keywords: Late onset sepsis, Bundle, Neonateshttp://www.sciencedirect.com/science/article/pii/S1413867014002049 |
| spellingShingle | Daiane Silva Resende Anna Laura Gil Peppe Heloisio dos Reis Vânia Olivetti Steffen Abdallah Rosineide Marques Ribas Paulo Pinto Gontijo Filho Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit Brazilian Journal of Infectious Diseases |
| title | Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit |
| title_full | Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit |
| title_fullStr | Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit |
| title_full_unstemmed | Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit |
| title_short | Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit |
| title_sort | late onset sepsis in newborn babies epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit |
| url | http://www.sciencedirect.com/science/article/pii/S1413867014002049 |
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