Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment
Metformin has been the first-line drug treatment for hyperglycemia and insulin resistance for over 50 years. However, the molecular basis of its therapeutic role remained incompletely understood. Recent advances demonstrate that metformin could exert its glucose-lowering effect by multiple mechanism...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01039/full |
| _version_ | 1819230694045384704 |
|---|---|
| author | Min Li Xiaoying Li Huijie Zhang Huijie Zhang Yan Lu |
| author_facet | Min Li Xiaoying Li Huijie Zhang Huijie Zhang Yan Lu |
| author_sort | Min Li |
| collection | DOAJ |
| description | Metformin has been the first-line drug treatment for hyperglycemia and insulin resistance for over 50 years. However, the molecular basis of its therapeutic role remained incompletely understood. Recent advances demonstrate that metformin could exert its glucose-lowering effect by multiple mechanisms, including activation of 5′-AMP-activated protein kinase, decreasing production of cyclic AMP, suppressing mitochondrial complex I of the electron transport chain, targeting glycerophosphate dehydrogenase, and altering the gut microbiome. In addition, epidemiological and clinical observation studies suggest that metformin reduced cancer risk in patients with type 2 diabetes and improved survival outcome of human cancers. Experimental studies have shown that this drug can inhibit cancer cell viability, growth, and proliferation through inhibiting mTORC1 signaling and mitochondrial complex I, suggesting that it may be a promising drug candidate for malignancy. Here, we summarize recent progress in studies of metformin in type 2 diabetes and tumorigenesis, which provides novel insight on the therapeutic development of human diseases. |
| first_indexed | 2024-12-23T11:33:08Z |
| format | Article |
| id | doaj.art-4564203c774c45458ff9c5f2672c61a9 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T11:33:08Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-4564203c774c45458ff9c5f2672c61a92022-12-21T17:48:44ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-07-01910.3389/fphys.2018.01039354854Molecular Mechanisms of Metformin for Diabetes and Cancer TreatmentMin Li0Xiaoying Li1Huijie Zhang2Huijie Zhang3Yan Lu4Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, ChinaMetformin has been the first-line drug treatment for hyperglycemia and insulin resistance for over 50 years. However, the molecular basis of its therapeutic role remained incompletely understood. Recent advances demonstrate that metformin could exert its glucose-lowering effect by multiple mechanisms, including activation of 5′-AMP-activated protein kinase, decreasing production of cyclic AMP, suppressing mitochondrial complex I of the electron transport chain, targeting glycerophosphate dehydrogenase, and altering the gut microbiome. In addition, epidemiological and clinical observation studies suggest that metformin reduced cancer risk in patients with type 2 diabetes and improved survival outcome of human cancers. Experimental studies have shown that this drug can inhibit cancer cell viability, growth, and proliferation through inhibiting mTORC1 signaling and mitochondrial complex I, suggesting that it may be a promising drug candidate for malignancy. Here, we summarize recent progress in studies of metformin in type 2 diabetes and tumorigenesis, which provides novel insight on the therapeutic development of human diseases.https://www.frontiersin.org/article/10.3389/fphys.2018.01039/fullmetformintype 2 diabetesgluconeogenesishepatic glucose productioncancercell proliferation |
| spellingShingle | Min Li Xiaoying Li Huijie Zhang Huijie Zhang Yan Lu Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment Frontiers in Physiology metformin type 2 diabetes gluconeogenesis hepatic glucose production cancer cell proliferation |
| title | Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment |
| title_full | Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment |
| title_fullStr | Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment |
| title_full_unstemmed | Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment |
| title_short | Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment |
| title_sort | molecular mechanisms of metformin for diabetes and cancer treatment |
| topic | metformin type 2 diabetes gluconeogenesis hepatic glucose production cancer cell proliferation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01039/full |
| work_keys_str_mv | AT minli molecularmechanismsofmetforminfordiabetesandcancertreatment AT xiaoyingli molecularmechanismsofmetforminfordiabetesandcancertreatment AT huijiezhang molecularmechanismsofmetforminfordiabetesandcancertreatment AT huijiezhang molecularmechanismsofmetforminfordiabetesandcancertreatment AT yanlu molecularmechanismsofmetforminfordiabetesandcancertreatment |