Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015)
OBJECTIVES: This report describes the extended follow-up (1941–2015) of a cohort of 38 549 automobile manufacturing workers with potential exposure to metalworking fluids (MWF). The outcomes of interest were mortality from cancers of the esophagus, stomach, intestine, rectum, bladder, liver, pancrea...
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| Format: | Article |
| Language: | English |
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Nordic Association of Occupational Safety and Health (NOROSH)
2020-09-01
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| Series: | Scandinavian Journal of Work, Environment & Health |
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| Online Access: |
https://www.sjweh.fi/show_abstract.php?abstract_id=3898
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| _version_ | 1819295024252190720 |
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| author | Sadie Costello Kevin Chen Sally Picciotto Liza Lutzker Ellen Eisen |
| author_facet | Sadie Costello Kevin Chen Sally Picciotto Liza Lutzker Ellen Eisen |
| author_sort | Sadie Costello |
| collection | DOAJ |
| description | OBJECTIVES: This report describes the extended follow-up (1941–2015) of a cohort of 38 549 automobile manufacturing workers with potential exposure to metalworking fluids (MWF). The outcomes of interest were mortality from cancers of the esophagus, stomach, intestine, rectum, bladder, liver, pancreas, larynx, lung, skin, prostate, brain, and female breast, as well as leukemia. This report includes 5472 deaths from cancer, more than ten times the numbers of deaths in our last summary report published 20 years ago. METHODS: Standardized mortality ratios were computed for the entire study period. Adjusted hazard ratios (HR) were estimated in Cox proportional hazard models with categorical variables for cumulative exposure to each type of MWF. RESULTS: Exposure–response patterns are consistent with prior mortality reports from this cohort. We found increased risk of skin and female breast cancer with straight fluids. For the first time, we found elevated risk of stomach cancer mortality. Overall, many of the exposure–response results did not suggest an association with MWF. CONCLUSIONS: Mortality is a poor proxy for cancer diagnosis for treatable cancers and not the optimal outcome measure in etiological studies. Although the HR presented here handle bias from the healthy worker hire effect and left truncation, they do not handle bias from healthy worker survivor effect, which likely results in underestimates of the health impacts of MWF. Although this updated summary provides some information on the risk of cancer from MWF, targeted future analyses will help clarify associations. |
| first_indexed | 2024-12-24T04:35:38Z |
| format | Article |
| id | doaj.art-4565541804f44da4bb5e366c1f8324a0 |
| institution | Directory Open Access Journal |
| issn | 0355-3140 1795-990X |
| language | English |
| last_indexed | 2024-12-24T04:35:38Z |
| publishDate | 2020-09-01 |
| publisher | Nordic Association of Occupational Safety and Health (NOROSH) |
| record_format | Article |
| series | Scandinavian Journal of Work, Environment & Health |
| spelling | doaj.art-4565541804f44da4bb5e366c1f8324a02022-12-21T17:15:12ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2020-09-0146552553210.5271/sjweh.38983898Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015)Sadie Costello0Kevin ChenSally PicciottoLiza LutzkerEllen EisenEnvironmental Health Science, School of Public Health, University of California, Berkeley, 2121 Berkeley Way #5302, Berkeley, CA 94720-7360, USA.OBJECTIVES: This report describes the extended follow-up (1941–2015) of a cohort of 38 549 automobile manufacturing workers with potential exposure to metalworking fluids (MWF). The outcomes of interest were mortality from cancers of the esophagus, stomach, intestine, rectum, bladder, liver, pancreas, larynx, lung, skin, prostate, brain, and female breast, as well as leukemia. This report includes 5472 deaths from cancer, more than ten times the numbers of deaths in our last summary report published 20 years ago. METHODS: Standardized mortality ratios were computed for the entire study period. Adjusted hazard ratios (HR) were estimated in Cox proportional hazard models with categorical variables for cumulative exposure to each type of MWF. RESULTS: Exposure–response patterns are consistent with prior mortality reports from this cohort. We found increased risk of skin and female breast cancer with straight fluids. For the first time, we found elevated risk of stomach cancer mortality. Overall, many of the exposure–response results did not suggest an association with MWF. CONCLUSIONS: Mortality is a poor proxy for cancer diagnosis for treatable cancers and not the optimal outcome measure in etiological studies. Although the HR presented here handle bias from the healthy worker hire effect and left truncation, they do not handle bias from healthy worker survivor effect, which likely results in underestimates of the health impacts of MWF. Although this updated summary provides some information on the risk of cancer from MWF, targeted future analyses will help clarify associations. https://www.sjweh.fi/show_abstract.php?abstract_id=3898 autoworkercox modelstandardized mortality ratiousauto manufacturingmetalworkingcohortexposurecancercohort analysismortalitycohort studycancer mortalitymetalworking fluid |
| spellingShingle | Sadie Costello Kevin Chen Sally Picciotto Liza Lutzker Ellen Eisen Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015) Scandinavian Journal of Work, Environment & Health autoworker cox model standardized mortality ratio us auto manufacturing metalworking cohort exposure cancer cohort analysis mortality cohort study cancer mortality metalworking fluid |
| title | Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015) |
| title_full | Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015) |
| title_fullStr | Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015) |
| title_full_unstemmed | Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015) |
| title_short | Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015) |
| title_sort | metalworking fluids and cancer mortality in a us autoworker cohort 1941 2015 |
| topic | autoworker cox model standardized mortality ratio us auto manufacturing metalworking cohort exposure cancer cohort analysis mortality cohort study cancer mortality metalworking fluid |
| url |
https://www.sjweh.fi/show_abstract.php?abstract_id=3898
|
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