PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN
Hypertension in pregnancy including chronic hypertension with or without pre-eclampsia, gestational hypertension increases maternal and infant mortality significantly. The treatment for hypertension in pregnancy is the administration of methyldopa. Methyldopa transdermal patch is made by mixing the...
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| Format: | Article |
| Language: | English |
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Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
2024-01-01
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| Series: | JIIS: Jurnal Ilmiah Ibnu Sina |
| Subjects: | |
| Online Access: | https://e-jurnal.stikes-isfi.ac.id/index.php/JIIS/article/view/1647 |
| _version_ | 1827325038062206976 |
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| author | Mayna Mayna Noval Noval Aisya Fitri Khairunnisa Olivia Octaviani Wilujeng Wilujeng |
| author_facet | Mayna Mayna Noval Noval Aisya Fitri Khairunnisa Olivia Octaviani Wilujeng Wilujeng |
| author_sort | Mayna Mayna |
| collection | DOAJ |
| description |
Hypertension in pregnancy including chronic hypertension with or without pre-eclampsia, gestational hypertension increases maternal and infant mortality significantly. The treatment for hypertension in pregnancy is the administration of methyldopa. Methyldopa transdermal patch is made by mixing the polymer first and then adding the active substance, namely methyldopa drug. It is intended that the polymer becomes an outer layer that controls the release of the drug. The resulting transdermal patch formulation was then evaluated, including organoleptic test, pH test, weight uniformity test, patch thickness test, folding resistance test, moisture test and penetration test using Franz diffusion cell. SPSS statistical data analysis. The penetration rate results showed F1 with 832.16 µg/cm2, F4 with 767.95 µg/cm2, F2 with 2819 µg/cm2 and F3 with 275.38 µg/cm2 all formulas have met the requirements. Based on the results of physical characteristics evaluation research, all formulas have met the requirements. The results of the in vitro evaluation of the methyldopa patch transdermal penetration test found that the difference in concentration in each formula had no significant effect on the penetration test. Based on physical evaluation parameters and in vitro penetration tests, the most optimal formula is F4 with the ratio of HPMC and ethyl cellulose (300:100) seen by fulfilling all physical characteristic evaluation tests and having a constant percent of cumulative amount to rise.
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| first_indexed | 2024-03-07T14:15:26Z |
| format | Article |
| id | doaj.art-4567d61eec3b44e981a6fa9b1e7cc7b5 |
| institution | Directory Open Access Journal |
| issn | 2502-647X 2503-1902 |
| language | English |
| last_indexed | 2024-03-07T14:15:26Z |
| publishDate | 2024-01-01 |
| publisher | Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin |
| record_format | Article |
| series | JIIS: Jurnal Ilmiah Ibnu Sina |
| spelling | doaj.art-4567d61eec3b44e981a6fa9b1e7cc7b52024-03-06T13:03:41ZengSekolah Tinggi Ilmu Kesehatan ISFI BanjarmasinJIIS: Jurnal Ilmiah Ibnu Sina2502-647X2503-19022024-01-0183PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILANMayna Mayna0Noval Noval1Aisya Fitri Khairunnisa2Olivia Octaviani3Wilujeng Wilujeng4Universitas Sari MuliaUniversitas Sari MuliaUniversitas Sari MuliaUniversitas Sari MuliaUniversitas Sari Mulia Hypertension in pregnancy including chronic hypertension with or without pre-eclampsia, gestational hypertension increases maternal and infant mortality significantly. The treatment for hypertension in pregnancy is the administration of methyldopa. Methyldopa transdermal patch is made by mixing the polymer first and then adding the active substance, namely methyldopa drug. It is intended that the polymer becomes an outer layer that controls the release of the drug. The resulting transdermal patch formulation was then evaluated, including organoleptic test, pH test, weight uniformity test, patch thickness test, folding resistance test, moisture test and penetration test using Franz diffusion cell. SPSS statistical data analysis. The penetration rate results showed F1 with 832.16 µg/cm2, F4 with 767.95 µg/cm2, F2 with 2819 µg/cm2 and F3 with 275.38 µg/cm2 all formulas have met the requirements. Based on the results of physical characteristics evaluation research, all formulas have met the requirements. The results of the in vitro evaluation of the methyldopa patch transdermal penetration test found that the difference in concentration in each formula had no significant effect on the penetration test. Based on physical evaluation parameters and in vitro penetration tests, the most optimal formula is F4 with the ratio of HPMC and ethyl cellulose (300:100) seen by fulfilling all physical characteristic evaluation tests and having a constant percent of cumulative amount to rise. https://e-jurnal.stikes-isfi.ac.id/index.php/JIIS/article/view/1647TransdermalPatchMethyldopaHypertension |
| spellingShingle | Mayna Mayna Noval Noval Aisya Fitri Khairunnisa Olivia Octaviani Wilujeng Wilujeng PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN JIIS: Jurnal Ilmiah Ibnu Sina Transdermal Patch Methyldopa Hypertension |
| title | PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN |
| title_full | PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN |
| title_fullStr | PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN |
| title_full_unstemmed | PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN |
| title_short | PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN |
| title_sort | pengembangan transdermal drug delivery system tdds patch methyldopa sebagai antihipertensi pada kehamilan |
| topic | Transdermal Patch Methyldopa Hypertension |
| url | https://e-jurnal.stikes-isfi.ac.id/index.php/JIIS/article/view/1647 |
| work_keys_str_mv | AT maynamayna pengembangantransdermaldrugdeliverysystemtddspatchmethyldopasebagaiantihipertensipadakehamilan AT novalnoval pengembangantransdermaldrugdeliverysystemtddspatchmethyldopasebagaiantihipertensipadakehamilan AT aisyafitrikhairunnisa pengembangantransdermaldrugdeliverysystemtddspatchmethyldopasebagaiantihipertensipadakehamilan AT oliviaoctaviani pengembangantransdermaldrugdeliverysystemtddspatchmethyldopasebagaiantihipertensipadakehamilan AT wilujengwilujeng pengembangantransdermaldrugdeliverysystemtddspatchmethyldopasebagaiantihipertensipadakehamilan |