CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection.
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of mice...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-06-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC1475660?pdf=render |
| _version_ | 1828156299295064064 |
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| author | Imtiaz A Khan Seddon Y Thomas Magali M Moretto Frederick S Lee Sabina A Islam Crescent Combe Joseph D Schwartzman Andrew D Luster |
| author_facet | Imtiaz A Khan Seddon Y Thomas Magali M Moretto Frederick S Lee Sabina A Islam Crescent Combe Joseph D Schwartzman Andrew D Luster |
| author_sort | Imtiaz A Khan |
| collection | DOAJ |
| description | The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of mice deficient in the chemokine receptor CCR5 following infection with the intracellular protozoan parasite Toxoplasma gondii. We found that CCR5 controls recruitment of natural killer (NK) cells into infected tissues. Without this influx of NK cells, tissues from CCR5-deficient (CCR5-/-) mice were less able to generate an inflammatory response, had decreased chemokine and interferon gamma production, and had higher parasite burden. As a result, CCR5-/- mice were more susceptible to infection with T. gondii but were less susceptible to the immune-mediated tissue injury seen in certain inbred strains. Adoptive transfer of CCR5+/+ NK cells into CCR5-/- mice restored their ability to survive lethal T. gondii infection and demonstrated that CCR5 is required for NK cell homing into infected liver and spleen. This study establishes CCR5 as a critical receptor guiding NK cell trafficking in host defense. |
| first_indexed | 2024-04-11T23:08:25Z |
| format | Article |
| id | doaj.art-4567ffbc98584134ad92c3e22ca4a72f |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-04-11T23:08:25Z |
| publishDate | 2006-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-4567ffbc98584134ad92c3e22ca4a72f2022-12-22T03:57:55ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742006-06-0126e4910.1371/journal.ppat.0020049CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection.Imtiaz A KhanSeddon Y ThomasMagali M MorettoFrederick S LeeSabina A IslamCrescent CombeJoseph D SchwartzmanAndrew D LusterThe host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of mice deficient in the chemokine receptor CCR5 following infection with the intracellular protozoan parasite Toxoplasma gondii. We found that CCR5 controls recruitment of natural killer (NK) cells into infected tissues. Without this influx of NK cells, tissues from CCR5-deficient (CCR5-/-) mice were less able to generate an inflammatory response, had decreased chemokine and interferon gamma production, and had higher parasite burden. As a result, CCR5-/- mice were more susceptible to infection with T. gondii but were less susceptible to the immune-mediated tissue injury seen in certain inbred strains. Adoptive transfer of CCR5+/+ NK cells into CCR5-/- mice restored their ability to survive lethal T. gondii infection and demonstrated that CCR5 is required for NK cell homing into infected liver and spleen. This study establishes CCR5 as a critical receptor guiding NK cell trafficking in host defense.http://europepmc.org/articles/PMC1475660?pdf=render |
| spellingShingle | Imtiaz A Khan Seddon Y Thomas Magali M Moretto Frederick S Lee Sabina A Islam Crescent Combe Joseph D Schwartzman Andrew D Luster CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathogens |
| title | CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. |
| title_full | CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. |
| title_fullStr | CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. |
| title_full_unstemmed | CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. |
| title_short | CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. |
| title_sort | ccr5 is essential for nk cell trafficking and host survival following toxoplasma gondii infection |
| url | http://europepmc.org/articles/PMC1475660?pdf=render |
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