Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management
Background: Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodefic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00586/full |
| _version_ | 1830300558615904256 |
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| author | Silvia Sánchez-Ramón Arancha Bermúdez Luis Ignacio González-Granado Carlos Rodríguez-Gallego Ana Sastre Pere Soler-Palacín the ID-Signal Onco-Haematology Group Luis Allende Laia Alsina Ana María Bielsa Sara Calleja-Antolín Carmen Cámara Javier Carbone Carmen Carreras Ana De Andrés Martín Angela Deyá Cristina Díaz de Heredia Romina Dieli-Crimi José Luis Díez Nerea Domínguez-Pinilla Luis Fernández-Pereira José Mᵃ García Juana Gil-Herrera Antonio Gutiérrez Isidro Jarque Manel Juan Francisco Lendínez Pilar Llobet Mónica López Ana López de la Guía Marcos López-Hoyos Andrea Martín-Nalda Mónica Martínez Josefa Melero Ana Méndez-Echevarría Pedro Moral Olaf Neth María Núñez Gonzalo Ocejo-Vinyals Juliana Ochoa-Grullón Peter Olbrich Raquel Oña Manuel Pérez-Encinas Jaime Pons Carmen Rodríguez Berta Sánchez Juan Luis Santos-Pérez Mᵃ Elena Seoane Alexandru Vlagea |
| author_facet | Silvia Sánchez-Ramón Arancha Bermúdez Luis Ignacio González-Granado Carlos Rodríguez-Gallego Ana Sastre Pere Soler-Palacín the ID-Signal Onco-Haematology Group Luis Allende Laia Alsina Ana María Bielsa Sara Calleja-Antolín Carmen Cámara Javier Carbone Carmen Carreras Ana De Andrés Martín Angela Deyá Cristina Díaz de Heredia Romina Dieli-Crimi José Luis Díez Nerea Domínguez-Pinilla Luis Fernández-Pereira José Mᵃ García Juana Gil-Herrera Antonio Gutiérrez Isidro Jarque Manel Juan Francisco Lendínez Pilar Llobet Mónica López Ana López de la Guía Marcos López-Hoyos Andrea Martín-Nalda Mónica Martínez Josefa Melero Ana Méndez-Echevarría Pedro Moral Olaf Neth María Núñez Gonzalo Ocejo-Vinyals Juliana Ochoa-Grullón Peter Olbrich Raquel Oña Manuel Pérez-Encinas Jaime Pons Carmen Rodríguez Berta Sánchez Juan Luis Santos-Pérez Mᵃ Elena Seoane Alexandru Vlagea |
| author_sort | Silvia Sánchez-Ramón |
| collection | DOAJ |
| description | Background: Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodeficiencies (SID) may also be induced by oncohaematological diseases and their treatments. Haematologists and oncologists must therefore be aware of the association between blood disorders and cancer and ID, and be prepared to offer their patients appropriate treatment without delay. Our aim was to define the warning signs of primary and secondary IDs in paediatric and adult patients with oncohaematological manifestations.Methods: A multidisciplinary group of six experts (2 haematologists, 2 immunologists, and 2 paediatricians specializing in ID) conducted a literature review and prepared a document based on agreements reached an in-person meeting. An external group of 44 IDs specialists from all over Spain assessed the document and were consulted regarding their level of agreement.Results: This document identifies the haematological and extra-haematological diseases that should prompt a suspicion of PIDs in adults and children, in both primary care and haematology and oncology departments. Cytopenia and certain lymphoproliferative disorders are key diagnostic pointers. The diagnosis must be based on a detailed clinical history, physical exploration, complete blood count and standard laboratory tests. The immunological and haematological tests included in the diagnostic process will depend on the care level. Patients who are candidates for immunoglobulin replacement therapy must be carefully selected, and treatment should be offered as soon as possible to avoid the development of complications. Finally, this document recommends procedures for monitoring these patients.Conclusions: This document combines scientific evidence with the opinion of a broad panel of experts, and emphasizes the importance of an early diagnosis and treatment to avoid complications. The resulting document is a useful tool for primary care physicians and specialists who see both adult and paediatric patients with oncohaematological diseases. |
| first_indexed | 2024-12-19T08:30:44Z |
| format | Article |
| id | doaj.art-4568dfcd26f44d75b61bebce1b8efe6a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T08:30:44Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4568dfcd26f44d75b61bebce1b8efe6a2022-12-21T20:29:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00586443461Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and ManagementSilvia Sánchez-Ramón0Arancha Bermúdez1Luis Ignacio González-Granado2Carlos Rodríguez-Gallego3Ana Sastre4Pere Soler-Palacín5the ID-Signal Onco-Haematology GroupLuis AllendeLaia AlsinaAna María BielsaSara Calleja-AntolínCarmen CámaraJavier CarboneCarmen CarrerasAna De Andrés MartínAngela DeyáCristina Díaz de HerediaRomina Dieli-CrimiJosé Luis DíezNerea Domínguez-PinillaLuis Fernández-PereiraJosé Mᵃ GarcíaJuana Gil-HerreraAntonio GutiérrezIsidro JarqueManel JuanFrancisco LendínezPilar LlobetMónica LópezAna López de la GuíaMarcos López-HoyosAndrea Martín-NaldaMónica MartínezJosefa MeleroAna Méndez-EchevarríaPedro MoralOlaf NethMaría NúñezGonzalo Ocejo-VinyalsJuliana Ochoa-GrullónPeter OlbrichRaquel OñaManuel Pérez-EncinasJaime PonsCarmen RodríguezBerta SánchezJuan Luis Santos-PérezMᵃ Elena SeoaneAlexandru VlageaHospital Clínico San Carlos, Madrid, SpainHospital U. Marqués de Valdecilla, Santander, SpainHospital U. 12 Octubre, Madrid, SpainHospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Canary Islands, SpainHospital U. La Paz, Madrid, SpainHospital U. Vall d'Hebron, Barcelona, SpainBackground: Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodeficiencies (SID) may also be induced by oncohaematological diseases and their treatments. Haematologists and oncologists must therefore be aware of the association between blood disorders and cancer and ID, and be prepared to offer their patients appropriate treatment without delay. Our aim was to define the warning signs of primary and secondary IDs in paediatric and adult patients with oncohaematological manifestations.Methods: A multidisciplinary group of six experts (2 haematologists, 2 immunologists, and 2 paediatricians specializing in ID) conducted a literature review and prepared a document based on agreements reached an in-person meeting. An external group of 44 IDs specialists from all over Spain assessed the document and were consulted regarding their level of agreement.Results: This document identifies the haematological and extra-haematological diseases that should prompt a suspicion of PIDs in adults and children, in both primary care and haematology and oncology departments. Cytopenia and certain lymphoproliferative disorders are key diagnostic pointers. The diagnosis must be based on a detailed clinical history, physical exploration, complete blood count and standard laboratory tests. The immunological and haematological tests included in the diagnostic process will depend on the care level. Patients who are candidates for immunoglobulin replacement therapy must be carefully selected, and treatment should be offered as soon as possible to avoid the development of complications. Finally, this document recommends procedures for monitoring these patients.Conclusions: This document combines scientific evidence with the opinion of a broad panel of experts, and emphasizes the importance of an early diagnosis and treatment to avoid complications. The resulting document is a useful tool for primary care physicians and specialists who see both adult and paediatric patients with oncohaematological diseases.https://www.frontiersin.org/article/10.3389/fimmu.2019.00586/fullimmunoglobulins/deficiencyantibodies/deficiencyimmunoglobulins/administration and dosageautoimmunityhematologic neoplasmsimmunologic deficiency syndromes |
| spellingShingle | Silvia Sánchez-Ramón Arancha Bermúdez Luis Ignacio González-Granado Carlos Rodríguez-Gallego Ana Sastre Pere Soler-Palacín the ID-Signal Onco-Haematology Group Luis Allende Laia Alsina Ana María Bielsa Sara Calleja-Antolín Carmen Cámara Javier Carbone Carmen Carreras Ana De Andrés Martín Angela Deyá Cristina Díaz de Heredia Romina Dieli-Crimi José Luis Díez Nerea Domínguez-Pinilla Luis Fernández-Pereira José Mᵃ García Juana Gil-Herrera Antonio Gutiérrez Isidro Jarque Manel Juan Francisco Lendínez Pilar Llobet Mónica López Ana López de la Guía Marcos López-Hoyos Andrea Martín-Nalda Mónica Martínez Josefa Melero Ana Méndez-Echevarría Pedro Moral Olaf Neth María Núñez Gonzalo Ocejo-Vinyals Juliana Ochoa-Grullón Peter Olbrich Raquel Oña Manuel Pérez-Encinas Jaime Pons Carmen Rodríguez Berta Sánchez Juan Luis Santos-Pérez Mᵃ Elena Seoane Alexandru Vlagea Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management Frontiers in Immunology immunoglobulins/deficiency antibodies/deficiency immunoglobulins/administration and dosage autoimmunity hematologic neoplasms immunologic deficiency syndromes |
| title | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management |
| title_full | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management |
| title_fullStr | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management |
| title_full_unstemmed | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management |
| title_short | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management |
| title_sort | primary and secondary immunodeficiency diseases in oncohaematology warning signs diagnosis and management |
| topic | immunoglobulins/deficiency antibodies/deficiency immunoglobulins/administration and dosage autoimmunity hematologic neoplasms immunologic deficiency syndromes |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00586/full |
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