Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems
Neurochemical recording techniques have expanded our understanding of the pathophysiology of neurological disorders, as well as the mechanisms of action of treatment modalities like deep brain stimulation (DBS). DBS is used to treat diseases such as Parkinson’s disease, Tourette syndrome, and obsess...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2020-12-01
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| Series: | Reviews in Analytical Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/revac-2020-0117 |
| _version_ | 1818692647671300096 |
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| author | Rojas Cabrera Juan M. Blair Price J. Rusheen Aaron E. Goyal Abhinav Jondal Danielle Barath Abhijeet S. Shin Hojin Chang Su-Youne Bennet Kevin E. Blaha Charles D. Lee Kendall H. Oh Yoonbae |
| author_facet | Rojas Cabrera Juan M. Blair Price J. Rusheen Aaron E. Goyal Abhinav Jondal Danielle Barath Abhijeet S. Shin Hojin Chang Su-Youne Bennet Kevin E. Blaha Charles D. Lee Kendall H. Oh Yoonbae |
| author_sort | Rojas Cabrera Juan M. |
| collection | DOAJ |
| description | Neurochemical recording techniques have expanded our understanding of the pathophysiology of neurological disorders, as well as the mechanisms of action of treatment modalities like deep brain stimulation (DBS). DBS is used to treat diseases such as Parkinson’s disease, Tourette syndrome, and obsessive-compulsive disorder, among others. Although DBS is effective at alleviating symptoms related to these diseases and improving the quality of life of these patients, the mechanism of action of DBS is currently not fully understood. A leading hypothesis is that DBS modulates the electrical field potential by modifying neuronal firing frequencies to non-pathological rates thus providing therapeutic relief. To address this gap in knowledge, recent advances in electrochemical sensing techniques have given insight into the importance of neurotransmitters, such as dopamine, serotonin, glutamate, and adenosine, in disease pathophysiology. These studies have also highlighted their potential use in tandem with electrophysiology to serve as biomarkers in disease diagnosis and progression monitoring, as well as characterize response to treatment. Here, we provide an overview of disease-relevant neurotransmitters and their roles and implications as biomarkers, as well as innovations to the biosensors used to record these biomarkers. Furthermore, we discuss currently available neurochemical and electrophysiological recording devices, and discuss their viability to be implemented into the development of a closed-loop DBS system. |
| first_indexed | 2024-12-17T13:01:07Z |
| format | Article |
| id | doaj.art-456d3b0e20fd45b6b996747130eb39f7 |
| institution | Directory Open Access Journal |
| issn | 0793-0135 2191-0189 |
| language | English |
| last_indexed | 2024-12-17T13:01:07Z |
| publishDate | 2020-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews in Analytical Chemistry |
| spelling | doaj.art-456d3b0e20fd45b6b996747130eb39f72022-12-21T21:47:21ZengDe GruyterReviews in Analytical Chemistry0793-01352191-01892020-12-0139118819910.1515/revac-2020-0117revac-2020-0117Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systemsRojas Cabrera Juan M.0Blair Price J.1Rusheen Aaron E.2Goyal Abhinav3Jondal Danielle4Barath Abhijeet S.5Shin Hojin6Chang Su-Youne7Bennet Kevin E.8Blaha Charles D.9Lee Kendall H.10Oh Yoonbae11Department of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesDepartment of Neurosurgery Research, Mayo Clinic, Rochester, MN 55902, United StatesNeurochemical recording techniques have expanded our understanding of the pathophysiology of neurological disorders, as well as the mechanisms of action of treatment modalities like deep brain stimulation (DBS). DBS is used to treat diseases such as Parkinson’s disease, Tourette syndrome, and obsessive-compulsive disorder, among others. Although DBS is effective at alleviating symptoms related to these diseases and improving the quality of life of these patients, the mechanism of action of DBS is currently not fully understood. A leading hypothesis is that DBS modulates the electrical field potential by modifying neuronal firing frequencies to non-pathological rates thus providing therapeutic relief. To address this gap in knowledge, recent advances in electrochemical sensing techniques have given insight into the importance of neurotransmitters, such as dopamine, serotonin, glutamate, and adenosine, in disease pathophysiology. These studies have also highlighted their potential use in tandem with electrophysiology to serve as biomarkers in disease diagnosis and progression monitoring, as well as characterize response to treatment. Here, we provide an overview of disease-relevant neurotransmitters and their roles and implications as biomarkers, as well as innovations to the biosensors used to record these biomarkers. Furthermore, we discuss currently available neurochemical and electrophysiological recording devices, and discuss their viability to be implemented into the development of a closed-loop DBS system.https://doi.org/10.1515/revac-2020-0117deep brain stimulationneuromodulationelectrochemistryelectrophysiologyclosed-loopvoltammetry |
| spellingShingle | Rojas Cabrera Juan M. Blair Price J. Rusheen Aaron E. Goyal Abhinav Jondal Danielle Barath Abhijeet S. Shin Hojin Chang Su-Youne Bennet Kevin E. Blaha Charles D. Lee Kendall H. Oh Yoonbae Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems Reviews in Analytical Chemistry deep brain stimulation neuromodulation electrochemistry electrophysiology closed-loop voltammetry |
| title | Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems |
| title_full | Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems |
| title_fullStr | Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems |
| title_full_unstemmed | Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems |
| title_short | Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems |
| title_sort | advances in neurochemical measurements a review of biomarkers and devices for the development of closed loop deep brain stimulation systems |
| topic | deep brain stimulation neuromodulation electrochemistry electrophysiology closed-loop voltammetry |
| url | https://doi.org/10.1515/revac-2020-0117 |
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