The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells

The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells

Doxorubicin (Dox) is one of the most widely used treatments for breast cancer, although limited by the well-documented cardiotoxicity and other off-target effects. Mesenchymal stem cell (MSC) secretome has shown immunomodulatory and regenerative properties, further potentiated under 3D conditions. T...

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Bibliographic Details
Main Authors: Ana S. Serras, Sérgio P. Camões, Bernardo Antunes, Vera M. Costa, Flávio Dionísio, Volkan Yazar, Rui Vitorino, Fernando Remião, Matilde Castro, Nuno G. Oliveira, Joana P. Miranda
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
doxorubicin
cardiotoxicity
mesenchymal stem cells
secretome
3D cultures
Online Access:https://www.mdpi.com/1422-0067/22/23/13072

Internet

https://www.mdpi.com/1422-0067/22/23/13072

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