Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/7/737 |
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| author | Akhilesh Bendre Vinayak Hegde Kanalli V. Ajeya Subrahmanya Thagare Manjunatha Derangula Somasekhara Varalakshmi K. Nadumane Krishna Kant Ho-Young Jung Wei-Song Hung Mahaveer D. Kurkuri |
| author_facet | Akhilesh Bendre Vinayak Hegde Kanalli V. Ajeya Subrahmanya Thagare Manjunatha Derangula Somasekhara Varalakshmi K. Nadumane Krishna Kant Ho-Young Jung Wei-Song Hung Mahaveer D. Kurkuri |
| author_sort | Akhilesh Bendre |
| collection | DOAJ |
| description | Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal—organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day. |
| first_indexed | 2024-03-11T01:14:27Z |
| format | Article |
| id | doaj.art-456e9710132242c39f4f10f006c1bf8c |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T01:14:27Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-456e9710132242c39f4f10f006c1bf8c2023-11-18T18:33:18ZengMDPI AGBiosensors2079-63742023-07-0113773710.3390/bios13070737Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug DeliveryAkhilesh Bendre0Vinayak Hegde1Kanalli V. Ajeya2Subrahmanya Thagare Manjunatha3Derangula Somasekhara4Varalakshmi K. Nadumane5Krishna Kant6Ho-Young Jung7Wei-Song Hung8Mahaveer D. Kurkuri9Centre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, IndiaCentre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, IndiaDepartment of Environment and Energy Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of KoreaAdvanced Membrane Materials Research Center, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, TaiwanDepartment of Biotechnology, JAIN (Deemed-to-be-University), School of Sciences, JC Road, 34, 1st Cross Road, Sudharna Nagar, Bengaluru 560027, Karnataka, IndiaDepartment of Biotechnology, JAIN (Deemed-to-be-University), School of Sciences, JC Road, 34, 1st Cross Road, Sudharna Nagar, Bengaluru 560027, Karnataka, IndiaBiomedical Research Center (CINBIO), University of Vigo, 36310 Vigo, SpainDepartment of Environment and Energy Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of KoreaAdvanced Membrane Materials Research Center, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, TaiwanCentre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, IndiaDrug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal—organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day.https://www.mdpi.com/2079-6374/13/7/737adsorptionMOFsmicrofluidic chipdrug deliverysodium alginate |
| spellingShingle | Akhilesh Bendre Vinayak Hegde Kanalli V. Ajeya Subrahmanya Thagare Manjunatha Derangula Somasekhara Varalakshmi K. Nadumane Krishna Kant Ho-Young Jung Wei-Song Hung Mahaveer D. Kurkuri Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery Biosensors adsorption MOFs microfluidic chip drug delivery sodium alginate |
| title | Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery |
| title_full | Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery |
| title_fullStr | Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery |
| title_full_unstemmed | Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery |
| title_short | Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery |
| title_sort | microfluidic assisted synthesis of metal organic framework alginate micro particles for sustained drug delivery |
| topic | adsorption MOFs microfluidic chip drug delivery sodium alginate |
| url | https://www.mdpi.com/2079-6374/13/7/737 |
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