Independent and sensory human mitochondrial functions reflecting symbiotic evolution
The bacterial origin of mitochondria has been a widely accepted as an event that occurred about 1.45 billion years ago and endowed cells with internal energy producing organelle. Thus, mitochondria have traditionally been viewed as subcellular organelle as any other – fully functionally dependent on...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1130197/full |
| _version_ | 1797804455135019008 |
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| author | George B. Stefano Pascal Büttiker Simon Weissenberger Tobias Esch Martin Anders Jiri Raboch Richard M. Kream Radek Ptacek |
| author_facet | George B. Stefano Pascal Büttiker Simon Weissenberger Tobias Esch Martin Anders Jiri Raboch Richard M. Kream Radek Ptacek |
| author_sort | George B. Stefano |
| collection | DOAJ |
| description | The bacterial origin of mitochondria has been a widely accepted as an event that occurred about 1.45 billion years ago and endowed cells with internal energy producing organelle. Thus, mitochondria have traditionally been viewed as subcellular organelle as any other – fully functionally dependent on the cell it is a part of. However, recent studies have given us evidence that mitochondria are more functionally independent than other organelles, as they can function outside the cells, engage in complex “social” interactions, and communicate with each other as well as other cellular components, bacteria and viruses. Furthermore, mitochondria move, assemble and organize upon sensing different environmental cues, using a process akin to bacterial quorum sensing. Therefore, taking all these lines of evidence into account we hypothesize that mitochondria need to be viewed and studied from a perspective of a more functionally independent entity. This view of mitochondria may lead to new insights into their biological function, and inform new strategies for treatment of disease associated with mitochondrial dysfunction. |
| first_indexed | 2024-03-13T05:37:24Z |
| format | Article |
| id | doaj.art-456ee5fd1266476eb8e28f49986a5c45 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-13T05:37:24Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-456ee5fd1266476eb8e28f49986a5c452023-06-14T05:36:03ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-06-011310.3389/fcimb.2023.11301971130197Independent and sensory human mitochondrial functions reflecting symbiotic evolutionGeorge B. Stefano0Pascal Büttiker1Simon Weissenberger2Tobias Esch3Martin Anders4Jiri Raboch5Richard M. Kream6Radek Ptacek7Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, CzechiaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, CzechiaDepartment of Psychology, University of New York in Prague, Prague, CzechiaInstitute for Integrative Health Care and Health Promotion, School of Medicine, Witten/Herdecke University, Witten, GermanyDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, CzechiaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, CzechiaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, CzechiaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, CzechiaThe bacterial origin of mitochondria has been a widely accepted as an event that occurred about 1.45 billion years ago and endowed cells with internal energy producing organelle. Thus, mitochondria have traditionally been viewed as subcellular organelle as any other – fully functionally dependent on the cell it is a part of. However, recent studies have given us evidence that mitochondria are more functionally independent than other organelles, as they can function outside the cells, engage in complex “social” interactions, and communicate with each other as well as other cellular components, bacteria and viruses. Furthermore, mitochondria move, assemble and organize upon sensing different environmental cues, using a process akin to bacterial quorum sensing. Therefore, taking all these lines of evidence into account we hypothesize that mitochondria need to be viewed and studied from a perspective of a more functionally independent entity. This view of mitochondria may lead to new insights into their biological function, and inform new strategies for treatment of disease associated with mitochondrial dysfunction.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1130197/fullmitochondriavirusindependent mitochondriasentinel mitochondriasensory mitochondriaexosomes |
| spellingShingle | George B. Stefano Pascal Büttiker Simon Weissenberger Tobias Esch Martin Anders Jiri Raboch Richard M. Kream Radek Ptacek Independent and sensory human mitochondrial functions reflecting symbiotic evolution Frontiers in Cellular and Infection Microbiology mitochondria virus independent mitochondria sentinel mitochondria sensory mitochondria exosomes |
| title | Independent and sensory human mitochondrial functions reflecting symbiotic evolution |
| title_full | Independent and sensory human mitochondrial functions reflecting symbiotic evolution |
| title_fullStr | Independent and sensory human mitochondrial functions reflecting symbiotic evolution |
| title_full_unstemmed | Independent and sensory human mitochondrial functions reflecting symbiotic evolution |
| title_short | Independent and sensory human mitochondrial functions reflecting symbiotic evolution |
| title_sort | independent and sensory human mitochondrial functions reflecting symbiotic evolution |
| topic | mitochondria virus independent mitochondria sentinel mitochondria sensory mitochondria exosomes |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1130197/full |
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