Clinical characteristics of patients with pituitary gigantism during puberty
Objective To compare the clinical characteristics between pituitary gigantism patients with different age of onset. Methods This study retrospectively summarized the clinical data of patients diagnosed with pituitary gigantism in Peking Union Medical College Hospital from 1990 to 2018. Patients w...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2020-09-01
|
| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2020-40-9-1247.pdf |
| _version_ | 1797365660705095680 |
|---|---|
| author | YANG Ying-ying, LUO Yun-yun, CHEN Shi, WANG Lin-jie, YAO Yong, DENG Kan, ZHU Hui-juan, PAN Hui |
| author_facet | YANG Ying-ying, LUO Yun-yun, CHEN Shi, WANG Lin-jie, YAO Yong, DENG Kan, ZHU Hui-juan, PAN Hui |
| author_sort | YANG Ying-ying, LUO Yun-yun, CHEN Shi, WANG Lin-jie, YAO Yong, DENG Kan, ZHU Hui-juan, PAN Hui |
| collection | DOAJ |
| description | Objective To compare the clinical characteristics between pituitary gigantism patients with different age of onset. Methods This study retrospectively summarized the clinical data of patients diagnosed with pituitary gigantism in Peking Union Medical College Hospital from 1990 to 2018. Patients were divided into two groups according to the age of disease onset: patients with the age range of onset between 10～15 years old and the rest of patients. Results A total of 28 patients with pituitary gigantism were included in the study. Among them, 22 patients were male, with a median duration of 11.0 years (7.0, 13.8). 78.5% of the patients had a rapid growth in height at the first consultation, with an average height of (190.2±17.5)cm and an average height SDS(Ht SDS) of +4.5± 1.6 at the time of diagnosis. The pituitary MRI of 92.9% of patients demonstrated pituitary macroadenomas, of which 42.9% were pituitary giant adenomas. This study showed that the maximum diameter of the tumor in group with the age of onset between 10 to 15 years was significantly higher than that of control group (the age of onset between 10 to 15 years old: 2.9±1.3 cm vs. control group: (1.9±0.8)cm, P＜0.05), the proportion of pituitary giant adenoma was also significantly higher than control group (the age of onset between 10 to 15 years old: 62.5% vs control group: 16.7%, P＜0.05). Long-term follow-up data showed that the proportion of combined treatment (surgery & medication & radiotherapy) in group with onset of age between 10 to 15 years old was higher than that of control group (the age of onset between 10 to 15 years old: 31.2% vs control group: 8.3%). However, the cure rate between two groups in the long-term follow-up did not reach statistical significance. Conclusions This study shows that pituitary gigantism patients during puberty are prone to have larger adenoma and are more likely to develop into a giant pituitary adenoma. It is recommended to focus on this population in clinical practice and more aggressive treatment should be considered if necessary. |
| first_indexed | 2024-03-08T16:52:49Z |
| format | Article |
| id | doaj.art-456f13ba27f2437d863026622df6bd41 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:52:49Z |
| publishDate | 2020-09-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-456f13ba27f2437d863026622df6bd412024-01-05T03:17:21ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252020-09-0140912471251Clinical characteristics of patients with pituitary gigantism during pubertyYANG Ying-ying, LUO Yun-yun, CHEN Shi, WANG Lin-jie, YAO Yong, DENG Kan, ZHU Hui-juan, PAN Hui01. Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission; ;2. Department of Neurosurgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, ChinaObjective To compare the clinical characteristics between pituitary gigantism patients with different age of onset. Methods This study retrospectively summarized the clinical data of patients diagnosed with pituitary gigantism in Peking Union Medical College Hospital from 1990 to 2018. Patients were divided into two groups according to the age of disease onset: patients with the age range of onset between 10～15 years old and the rest of patients. Results A total of 28 patients with pituitary gigantism were included in the study. Among them, 22 patients were male, with a median duration of 11.0 years (7.0, 13.8). 78.5% of the patients had a rapid growth in height at the first consultation, with an average height of (190.2±17.5)cm and an average height SDS(Ht SDS) of +4.5± 1.6 at the time of diagnosis. The pituitary MRI of 92.9% of patients demonstrated pituitary macroadenomas, of which 42.9% were pituitary giant adenomas. This study showed that the maximum diameter of the tumor in group with the age of onset between 10 to 15 years was significantly higher than that of control group (the age of onset between 10 to 15 years old: 2.9±1.3 cm vs. control group: (1.9±0.8)cm, P＜0.05), the proportion of pituitary giant adenoma was also significantly higher than control group (the age of onset between 10 to 15 years old: 62.5% vs control group: 16.7%, P＜0.05). Long-term follow-up data showed that the proportion of combined treatment (surgery & medication & radiotherapy) in group with onset of age between 10 to 15 years old was higher than that of control group (the age of onset between 10 to 15 years old: 31.2% vs control group: 8.3%). However, the cure rate between two groups in the long-term follow-up did not reach statistical significance. Conclusions This study shows that pituitary gigantism patients during puberty are prone to have larger adenoma and are more likely to develop into a giant pituitary adenoma. It is recommended to focus on this population in clinical practice and more aggressive treatment should be considered if necessary.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2020-40-9-1247.pdfpituitary gigantism|growth hormone-secreting pituitary adenomas|pituitary giant adenoma |
| spellingShingle | YANG Ying-ying, LUO Yun-yun, CHEN Shi, WANG Lin-jie, YAO Yong, DENG Kan, ZHU Hui-juan, PAN Hui Clinical characteristics of patients with pituitary gigantism during puberty Jichu yixue yu linchuang pituitary gigantism|growth hormone-secreting pituitary adenomas|pituitary giant adenoma |
| title | Clinical characteristics of patients with pituitary gigantism during puberty |
| title_full | Clinical characteristics of patients with pituitary gigantism during puberty |
| title_fullStr | Clinical characteristics of patients with pituitary gigantism during puberty |
| title_full_unstemmed | Clinical characteristics of patients with pituitary gigantism during puberty |
| title_short | Clinical characteristics of patients with pituitary gigantism during puberty |
| title_sort | clinical characteristics of patients with pituitary gigantism during puberty |
| topic | pituitary gigantism|growth hormone-secreting pituitary adenomas|pituitary giant adenoma |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2020-40-9-1247.pdf |
| work_keys_str_mv | AT yangyingyingluoyunyunchenshiwanglinjieyaoyongdengkanzhuhuijuanpanhui clinicalcharacteristicsofpatientswithpituitarygigantismduringpuberty |