Approaches to Establishing Tolerance in Immune Mediated Diseases
The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune T...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.744804/full |
| _version_ | 1819071407617736704 |
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| author | Michelle F. Huffaker Srinath Sanda Sindhu Chandran Sharon A. Chung E. William St. Clair Gerald T. Nepom Dawn E. Smilek |
| author_facet | Michelle F. Huffaker Srinath Sanda Sindhu Chandran Sharon A. Chung E. William St. Clair Gerald T. Nepom Dawn E. Smilek |
| author_sort | Michelle F. Huffaker |
| collection | DOAJ |
| description | The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance. |
| first_indexed | 2024-12-21T17:21:21Z |
| format | Article |
| id | doaj.art-456ffed289e8483883fd5f8b1dd4ad4a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T17:21:21Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-456ffed289e8483883fd5f8b1dd4ad4a2022-12-21T18:56:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-09-011210.3389/fimmu.2021.744804744804Approaches to Establishing Tolerance in Immune Mediated DiseasesMichelle F. Huffaker0Srinath Sanda1Sindhu Chandran2Sharon A. Chung3E. William St. Clair4Gerald T. Nepom5Dawn E. Smilek6Immune Tolerance Network, University of California San Francisco, San Francisco, CA, United StatesImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United StatesImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United StatesImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United StatesImmune Tolerance Network, Duke University, Durham, NC, United StatesImmune Tolerance Network, Benaroya Research Institute, Seattle, WA, United StatesImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United StatesThe development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.https://www.frontiersin.org/articles/10.3389/fimmu.2021.744804/fullimmune toleranceallergytransplantationautoimmunityclinical trialimmunomodulation |
| spellingShingle | Michelle F. Huffaker Srinath Sanda Sindhu Chandran Sharon A. Chung E. William St. Clair Gerald T. Nepom Dawn E. Smilek Approaches to Establishing Tolerance in Immune Mediated Diseases Frontiers in Immunology immune tolerance allergy transplantation autoimmunity clinical trial immunomodulation |
| title | Approaches to Establishing Tolerance in Immune Mediated Diseases |
| title_full | Approaches to Establishing Tolerance in Immune Mediated Diseases |
| title_fullStr | Approaches to Establishing Tolerance in Immune Mediated Diseases |
| title_full_unstemmed | Approaches to Establishing Tolerance in Immune Mediated Diseases |
| title_short | Approaches to Establishing Tolerance in Immune Mediated Diseases |
| title_sort | approaches to establishing tolerance in immune mediated diseases |
| topic | immune tolerance allergy transplantation autoimmunity clinical trial immunomodulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.744804/full |
| work_keys_str_mv | AT michellefhuffaker approachestoestablishingtoleranceinimmunemediateddiseases AT srinathsanda approachestoestablishingtoleranceinimmunemediateddiseases AT sindhuchandran approachestoestablishingtoleranceinimmunemediateddiseases AT sharonachung approachestoestablishingtoleranceinimmunemediateddiseases AT ewilliamstclair approachestoestablishingtoleranceinimmunemediateddiseases AT geraldtnepom approachestoestablishingtoleranceinimmunemediateddiseases AT dawnesmilek approachestoestablishingtoleranceinimmunemediateddiseases |