Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions
Objective To investigate the role of quantitative analysis of T2 relaxation time in the magnetic resonance imaging (MRI) diagnosis of breast cancer. Methods The study enrolled patients with clinical breast masses who were examined using MRI at eight different echo times. The differences in T2 relaxa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060517721071 |
| _version_ | 1818402582950838272 |
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| author | Li Liu Bo Yin Kawai Shek Daoying Geng Yiping Lu Jianbo Wen Xinping Kuai Weijun Peng |
| author_facet | Li Liu Bo Yin Kawai Shek Daoying Geng Yiping Lu Jianbo Wen Xinping Kuai Weijun Peng |
| author_sort | Li Liu |
| collection | DOAJ |
| description | Objective To investigate the role of quantitative analysis of T2 relaxation time in the magnetic resonance imaging (MRI) diagnosis of breast cancer. Methods The study enrolled patients with clinical breast masses who were examined using MRI at eight different echo times. The differences in T2 relaxation time of benign and malignant breast lesions were analysed. Results A total of 67 patients (67 breast lesions: 46 malignant, 21 benign) were examined. The mean ± SD T2 relaxation time was significantly lower in the 46 malignant lesions compared with the 21 benign lesions (82.69 ± 15.37 ms versus 95.48 ± 26.51 ms, respectively). The area under the curve was 0.731. Using 79.52 ms as the cut-off between benign and malignant breast lesions, a sensitivity of 85.7% and a specificity of 58.7% were obtained. Conclusions There was a significant difference in T2 relaxation time between benign and malignant breast lesions. The specificity of using T2 relaxation time alone for the differentiation of benign from malignant lesions was not high, but it could constitute a new adjunct in the MRI diagnosis of breast cancer. |
| first_indexed | 2024-12-14T08:10:40Z |
| format | Article |
| id | doaj.art-4570c96482004ac1aee6ffe60020d6ae |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-14T08:10:40Z |
| publishDate | 2018-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-4570c96482004ac1aee6ffe60020d6ae2022-12-21T23:10:04ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002018-05-014610.1177/0300060517721071Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesionsLi Liu0Bo Yin1Kawai Shek2Daoying Geng3Yiping Lu4Jianbo Wen5Xinping Kuai6Weijun Peng7Department of Radiology, , Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Queen Elizabeth Hospital, Hong KongDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, , Shanghai Medical College, Fudan University, Shanghai, ChinaObjective To investigate the role of quantitative analysis of T2 relaxation time in the magnetic resonance imaging (MRI) diagnosis of breast cancer. Methods The study enrolled patients with clinical breast masses who were examined using MRI at eight different echo times. The differences in T2 relaxation time of benign and malignant breast lesions were analysed. Results A total of 67 patients (67 breast lesions: 46 malignant, 21 benign) were examined. The mean ± SD T2 relaxation time was significantly lower in the 46 malignant lesions compared with the 21 benign lesions (82.69 ± 15.37 ms versus 95.48 ± 26.51 ms, respectively). The area under the curve was 0.731. Using 79.52 ms as the cut-off between benign and malignant breast lesions, a sensitivity of 85.7% and a specificity of 58.7% were obtained. Conclusions There was a significant difference in T2 relaxation time between benign and malignant breast lesions. The specificity of using T2 relaxation time alone for the differentiation of benign from malignant lesions was not high, but it could constitute a new adjunct in the MRI diagnosis of breast cancer.https://doi.org/10.1177/0300060517721071 |
| spellingShingle | Li Liu Bo Yin Kawai Shek Daoying Geng Yiping Lu Jianbo Wen Xinping Kuai Weijun Peng Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions Journal of International Medical Research |
| title | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
| title_full | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
| title_fullStr | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
| title_full_unstemmed | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
| title_short | Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions |
| title_sort | role of quantitative analysis of t2 relaxation time in differentiating benign from malignant breast lesions |
| url | https://doi.org/10.1177/0300060517721071 |
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