Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring
As the main metabolic and detoxification organ, the liver constantly adapts its activity to fulfill the energy requirements of the whole body. Despite the remarkable adaptive capacity of the liver, prolonged exposure to noxious stimuli such as alcohol, viruses and metabolic disorders results in the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/5/417 |
| _version_ | 1797763207758086144 |
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| author | Tommaso Mello Irene Simeone Andrea Galli |
| author_facet | Tommaso Mello Irene Simeone Andrea Galli |
| author_sort | Tommaso Mello |
| collection | DOAJ |
| description | As the main metabolic and detoxification organ, the liver constantly adapts its activity to fulfill the energy requirements of the whole body. Despite the remarkable adaptive capacity of the liver, prolonged exposure to noxious stimuli such as alcohol, viruses and metabolic disorders results in the development of chronic liver disease that can progress to hepatocellular carcinoma (HCC), which is currently the second leading cause of cancer-related death worldwide. Metabolic rewiring is a common feature of cancers, including HCC. Altered mito-nuclear communication is emerging as a driving force in the metabolic reprogramming of cancer cells, affecting all aspects of cancer biology from neoplastic transformation to acquired drug resistance. Here, we explore relevant aspects (and discuss recent findings) of mito-nuclear crosstalk in the metabolic reprogramming of hepatocellular carcinoma. |
| first_indexed | 2024-03-12T19:38:15Z |
| format | Article |
| id | doaj.art-4571257af64345deaaaa01d1e82f18ce |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:38:15Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4571257af64345deaaaa01d1e82f18ce2023-08-02T04:01:41ZengMDPI AGCells2073-44092019-05-018541710.3390/cells8050417cells8050417Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic RewiringTommaso Mello0Irene Simeone1Andrea Galli2Clinical Gastroenterology Unit, Department of Biomedical Clinical and Experimental Sciences “Mario Serio”, University of Florence, V.le Pieraccini 6, Florence 50129, ItalyClinical Gastroenterology Unit, Department of Biomedical Clinical and Experimental Sciences “Mario Serio”, University of Florence, V.le Pieraccini 6, Florence 50129, ItalyClinical Gastroenterology Unit, Department of Biomedical Clinical and Experimental Sciences “Mario Serio”, University of Florence, V.le Pieraccini 6, Florence 50129, ItalyAs the main metabolic and detoxification organ, the liver constantly adapts its activity to fulfill the energy requirements of the whole body. Despite the remarkable adaptive capacity of the liver, prolonged exposure to noxious stimuli such as alcohol, viruses and metabolic disorders results in the development of chronic liver disease that can progress to hepatocellular carcinoma (HCC), which is currently the second leading cause of cancer-related death worldwide. Metabolic rewiring is a common feature of cancers, including HCC. Altered mito-nuclear communication is emerging as a driving force in the metabolic reprogramming of cancer cells, affecting all aspects of cancer biology from neoplastic transformation to acquired drug resistance. Here, we explore relevant aspects (and discuss recent findings) of mito-nuclear crosstalk in the metabolic reprogramming of hepatocellular carcinoma.https://www.mdpi.com/2073-4409/8/5/417HCCPPARSIRTPGC-1NRFHIFlivermitochondriametabolism |
| spellingShingle | Tommaso Mello Irene Simeone Andrea Galli Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring Cells HCC PPAR SIRT PGC-1 NRF HIF liver mitochondria metabolism |
| title | Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring |
| title_full | Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring |
| title_fullStr | Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring |
| title_full_unstemmed | Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring |
| title_short | Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring |
| title_sort | mito nuclear communication in hepatocellular carcinoma metabolic rewiring |
| topic | HCC PPAR SIRT PGC-1 NRF HIF liver mitochondria metabolism |
| url | https://www.mdpi.com/2073-4409/8/5/417 |
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