Inhibitory Effective Perturbations of Cilobradine (DK-AH269), A Blocker of HCN Channels, on the Amplitude and Gating of Both Hyperpolarization-Activated Cation and Delayed-Rectifier Potassium Currents
Cilobradine (CIL, DK-AH269), an inhibitor of hyperpolarization-activated cation current (<i>I</i><sub>h</sub>), has been observed to possess pro-arrhythmic properties. Whether and how CIL is capable of perturbing different types of membrane ionic currents existing in electric...
Main Authors: | Te-Ling Lu, Te-Jung Lu, Sheng-Nan Wu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/7/2416 |
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