Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and Favor Trypanosoma cruzi Infection in the BALB/c Mice Model of Experimental Chagas Disease

Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and Favor Trypanosoma cruzi Infection in the BALB/c Mice Model of Experimental Chagas Disease

Trypanosoma cruzi cruzipain (Cz) bears a C-terminal domain (C-T) that contains sulfated epitopes “sulfotopes” (GlcNAc6S) on its unique N-glycosylation site. The effects of in vivo exposure to GlcNAc6S on heart tissue ultrastructure, immune responses, and along the outcome of infection by T. cruzi, w...

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Bibliographic Details
Main Authors: Luciana L. Soprano, Maximiliano R. Ferrero, Malena Landoni, Gabriela A. García, Mónica I. Esteva, Alicia S. Couto, Vilma G. Duschak
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
cruzipain
C-T domain
sulfotopes
cruzipain sulfotope-specific antibodies
Chagas disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.814276/full

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