EGFR and PI3K Pathway Activities Might Guide Drug Repurposing in HPV-Negative Head and Neck Cancers

EGFR and PI3K Pathway Activities Might Guide Drug Repurposing in HPV-Negative Head and Neck Cancers

While genetic alterations in Epidermal growth factor receptor (EGFR) and PI3K are common in head and neck squamous cell carcinomas (HNSCC), their impact on oncogenic signaling and cancer drug sensitivities remains elusive. To determine their consequences on the transcriptional network, pathway activ...

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Bibliographic Details
Main Authors: Andreas Mock, Michaela Plath, Julius Moratin, Maria Johanna Tapken, Dirk Jäger, Jürgen Krauss, Stefan Fröhling, Jochen Hess, Karim Zaoui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
precision oncology
targeted therapy
head and neck squamous cell carcinoma
omics
systems biology
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.678966/full

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