Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor
ObjectivePatients with essential tremor (ET) may experience cognitive-affective impairment. Deep brain stimulation (DBS) of different targets, such as the ventral intermediate nucleus (VIM) of the thalamus or the posterior subthalamic area (PSA), has been shown to be beneficial for refractory ET. Ho...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1222592/full |
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| author | Lucía Triguero-Cueva Lucía Triguero-Cueva Bartolomé Marín-Romero Carlos Javier Madrid-Navarro Carlos Javier Madrid-Navarro María José Pérez-Navarro Benjamin Iáñez-Velasco Adolfo Mínguez-Castellanos Adolfo Mínguez-Castellanos Majed Jouma Katati Francisco Escamilla-Sevilla Francisco Escamilla-Sevilla |
| author_facet | Lucía Triguero-Cueva Lucía Triguero-Cueva Bartolomé Marín-Romero Carlos Javier Madrid-Navarro Carlos Javier Madrid-Navarro María José Pérez-Navarro Benjamin Iáñez-Velasco Adolfo Mínguez-Castellanos Adolfo Mínguez-Castellanos Majed Jouma Katati Francisco Escamilla-Sevilla Francisco Escamilla-Sevilla |
| author_sort | Lucía Triguero-Cueva |
| collection | DOAJ |
| description | ObjectivePatients with essential tremor (ET) may experience cognitive-affective impairment. Deep brain stimulation (DBS) of different targets, such as the ventral intermediate nucleus (VIM) of the thalamus or the posterior subthalamic area (PSA), has been shown to be beneficial for refractory ET. However, there is little evidence regarding the possible neuropsychological effects of PSA-DBS on patients with ET, and there are few studies comparing it with VIM-DBS in this population.In this study, we aim to present the evaluation protocol and neuropsychological battery as used in an ongoing trial of DBS for ET comparing the already mentioned targets.MethodsAs part of a randomized, double-blind, crossover clinical trial comparing the effectiveness and safety of PSA-DBS vs. VIM-DBS, 11 patients with refractory ET will undergo a multi-domain neuropsychological battery assessment. This will include a pre−/post-implantation assessment (3 months after the stimulation of each target and 6 months after an open stage of DBS on the most optimal target).ConclusionEvidence on the neuropsychological effects of DBS in patients with refractory ET is very scarce, particularly in lesser-explored targets such as PSA. This study could contribute significantly in this field, particularly on pre-procedure safety analysis for tailored patient/technique selection, and to complete the safety analysis of the procedure. Moreover, if proven useful, this proposed neuropsychological assessment protocol could be extensible to other surgical therapies for ET. |
| first_indexed | 2024-03-11T14:38:51Z |
| format | Article |
| id | doaj.art-457501756ddc4f77993fca42860e704a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T14:38:51Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-457501756ddc4f77993fca42860e704a2023-10-30T15:46:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12225921222592Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremorLucía Triguero-Cueva0Lucía Triguero-Cueva1Bartolomé Marín-Romero2Carlos Javier Madrid-Navarro3Carlos Javier Madrid-Navarro4María José Pérez-Navarro5Benjamin Iáñez-Velasco6Adolfo Mínguez-Castellanos7Adolfo Mínguez-Castellanos8Majed Jouma Katati9Francisco Escamilla-Sevilla10Francisco Escamilla-Sevilla11Department of Neurology Hospital Universitario Virgen de las Nieves, Granada, SpainInstituto de Investigación Biosanitaria ibs. GRANADA, Granada, SpainDepartment of Neuropsychology Hospital Universitario Virgen de las Nieves, Granada, SpainDepartment of Neurology Hospital Universitario Virgen de las Nieves, Granada, SpainInstituto de Investigación Biosanitaria ibs. GRANADA, Granada, SpainDepartment of Neurology Hospital Universitario Virgen de las Nieves, Granada, SpainDepartment of Neurosurgery Hospital Universitario Virgen de las Nieves, Granada, SpainDepartment of Neurology Hospital Universitario Virgen de las Nieves, Granada, SpainInstituto de Investigación Biosanitaria ibs. GRANADA, Granada, SpainDepartment of Neurosurgery Hospital Universitario Virgen de las Nieves, Granada, SpainDepartment of Neurology Hospital Universitario Virgen de las Nieves, Granada, SpainInstituto de Investigación Biosanitaria ibs. GRANADA, Granada, SpainObjectivePatients with essential tremor (ET) may experience cognitive-affective impairment. Deep brain stimulation (DBS) of different targets, such as the ventral intermediate nucleus (VIM) of the thalamus or the posterior subthalamic area (PSA), has been shown to be beneficial for refractory ET. However, there is little evidence regarding the possible neuropsychological effects of PSA-DBS on patients with ET, and there are few studies comparing it with VIM-DBS in this population.In this study, we aim to present the evaluation protocol and neuropsychological battery as used in an ongoing trial of DBS for ET comparing the already mentioned targets.MethodsAs part of a randomized, double-blind, crossover clinical trial comparing the effectiveness and safety of PSA-DBS vs. VIM-DBS, 11 patients with refractory ET will undergo a multi-domain neuropsychological battery assessment. This will include a pre−/post-implantation assessment (3 months after the stimulation of each target and 6 months after an open stage of DBS on the most optimal target).ConclusionEvidence on the neuropsychological effects of DBS in patients with refractory ET is very scarce, particularly in lesser-explored targets such as PSA. This study could contribute significantly in this field, particularly on pre-procedure safety analysis for tailored patient/technique selection, and to complete the safety analysis of the procedure. Moreover, if proven useful, this proposed neuropsychological assessment protocol could be extensible to other surgical therapies for ET.https://www.frontiersin.org/articles/10.3389/fneur.2023.1222592/fullcognitive-affective impairmentdeep brain stimulationessential tremorneuropsychological assessmentposterior subthalamic areaventral intermediate nucleus |
| spellingShingle | Lucía Triguero-Cueva Lucía Triguero-Cueva Bartolomé Marín-Romero Carlos Javier Madrid-Navarro Carlos Javier Madrid-Navarro María José Pérez-Navarro Benjamin Iáñez-Velasco Adolfo Mínguez-Castellanos Adolfo Mínguez-Castellanos Majed Jouma Katati Francisco Escamilla-Sevilla Francisco Escamilla-Sevilla Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor Frontiers in Neurology cognitive-affective impairment deep brain stimulation essential tremor neuropsychological assessment posterior subthalamic area ventral intermediate nucleus |
| title | Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor |
| title_full | Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor |
| title_fullStr | Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor |
| title_full_unstemmed | Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor |
| title_short | Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor |
| title_sort | neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs ventral intermediate nucleus deep brain stimulation for essential tremor |
| topic | cognitive-affective impairment deep brain stimulation essential tremor neuropsychological assessment posterior subthalamic area ventral intermediate nucleus |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1222592/full |
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