Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used n...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/4/375 |
| _version_ | 1797537917594238976 |
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| author | Rakefet Pando Shahar Stern Ital Nemet Aharona Glatman-Freedman Hanna Sefty Neta S. Zuckerman Yaron Drori Nehemya Friedman John W. McCauley Lital Keinan-Boker Ella Mendelson Rodney S. Daniels Michal Mandelboim |
| author_facet | Rakefet Pando Shahar Stern Ital Nemet Aharona Glatman-Freedman Hanna Sefty Neta S. Zuckerman Yaron Drori Nehemya Friedman John W. McCauley Lital Keinan-Boker Ella Mendelson Rodney S. Daniels Michal Mandelboim |
| author_sort | Rakefet Pando |
| collection | DOAJ |
| description | While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines. |
| first_indexed | 2024-03-10T12:23:04Z |
| format | Article |
| id | doaj.art-457598cbd4e446d1b7f668ad0423e45b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T12:23:04Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-457598cbd4e446d1b7f668ad0423e45b2023-11-21T15:17:15ZengMDPI AGVaccines2076-393X2021-04-019437510.3390/vaccines9040375Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 SeasonRakefet Pando0Shahar Stern1Ital Nemet2Aharona Glatman-Freedman3Hanna Sefty4Neta S. Zuckerman5Yaron Drori6Nehemya Friedman7John W. McCauley8Lital Keinan-Boker9Ella Mendelson10Rodney S. Daniels11Michal Mandelboim12The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, IsraelChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, IsraelChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, IsraelThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, IsraelThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, IsraelThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, IsraelChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, IsraelChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, IsraelWorldwide Influenza Center, The Francis Crick Institute, London NW1 1AT, UKThe Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Ramat-Gan 52621, IsraelChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, IsraelWorldwide Influenza Center, The Francis Crick Institute, London NW1 1AT, UKChaim Sheba Medical Center, Central Virology Laboratory, Ministry of Health, Ramat-Gan 52621, IsraelWhile vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.https://www.mdpi.com/2076-393X/9/4/375influenza Acirculationcladevaccine |
| spellingShingle | Rakefet Pando Shahar Stern Ital Nemet Aharona Glatman-Freedman Hanna Sefty Neta S. Zuckerman Yaron Drori Nehemya Friedman John W. McCauley Lital Keinan-Boker Ella Mendelson Rodney S. Daniels Michal Mandelboim Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season Vaccines influenza A circulation clade vaccine |
| title | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
| title_full | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
| title_fullStr | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
| title_full_unstemmed | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
| title_short | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
| title_sort | diversity in the circulation of influenza a h3n2 viruses in the northern hemisphere in the 2018 19 season |
| topic | influenza A circulation clade vaccine |
| url | https://www.mdpi.com/2076-393X/9/4/375 |
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