Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD
<p>Abstract</p> <p>Background</p> <p>Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas Transforming Growth Fac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://respiratory-research.com/content/13/1/116 |
| _version_ | 1811260848968040448 |
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| author | Stoll Paul Wuertemberger Urs Bratke Kai Zingler Christiana Virchow J Christian Lommatzsch Marek |
| author_facet | Stoll Paul Wuertemberger Urs Bratke Kai Zingler Christiana Virchow J Christian Lommatzsch Marek |
| author_sort | Stoll Paul |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas Transforming Growth Factor-β<sub>1</sub> (TGF-β<sub>1</sub>) plays a crucial role in tissue repair and emphysema pathogenesis. Both mediators are stored in platelets and released from platelets in inflammatory conditions and during serum preparation. In patients with asthma, it was previously shown that elevated serum BDNF concentrations correlate with disease severity, whereas TGF-β<sub>1</sub> concentrations were normal.</p> <p>Methods</p> <p>In the present study, 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls were studied. Lung function, smoking history, medication, platelet concentrations in peripheral blood and serum concentrations of BDNF, TGF-β<sub>1</sub> and Serotonin (5-HT) were assessed in all participants.</p> <p>Results</p> <p>Serum levels of both BDNF and TGF-β<sub>1</sub> (but not concentrations of platelets in peripheral blood) were significantly elevated in all stages of COPD as compared to controls. Highest BDNF concentrations were found in spirometric GOLD stage 3, whereas highest TGF-β<sub>1</sub> serum levels were found in spirometric GOLD stage 4. There were specific, stage-dependent correlations of these mediators with lung function parameters of the patients.</p> <p>Conclusions</p> <p>Taken together, we show that, in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-β<sub>1</sub> in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD.</p> |
| first_indexed | 2024-04-12T18:53:49Z |
| format | Article |
| id | doaj.art-4576bc9e777249f8844da8fc1a17d396 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-04-12T18:53:49Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-4576bc9e777249f8844da8fc1a17d3962022-12-22T03:20:24ZengBMCRespiratory Research1465-99212012-12-0113111610.1186/1465-9921-13-116Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPDStoll PaulWuertemberger UrsBratke KaiZingler ChristianaVirchow J ChristianLommatzsch Marek<p>Abstract</p> <p>Background</p> <p>Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas Transforming Growth Factor-β<sub>1</sub> (TGF-β<sub>1</sub>) plays a crucial role in tissue repair and emphysema pathogenesis. Both mediators are stored in platelets and released from platelets in inflammatory conditions and during serum preparation. In patients with asthma, it was previously shown that elevated serum BDNF concentrations correlate with disease severity, whereas TGF-β<sub>1</sub> concentrations were normal.</p> <p>Methods</p> <p>In the present study, 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls were studied. Lung function, smoking history, medication, platelet concentrations in peripheral blood and serum concentrations of BDNF, TGF-β<sub>1</sub> and Serotonin (5-HT) were assessed in all participants.</p> <p>Results</p> <p>Serum levels of both BDNF and TGF-β<sub>1</sub> (but not concentrations of platelets in peripheral blood) were significantly elevated in all stages of COPD as compared to controls. Highest BDNF concentrations were found in spirometric GOLD stage 3, whereas highest TGF-β<sub>1</sub> serum levels were found in spirometric GOLD stage 4. There were specific, stage-dependent correlations of these mediators with lung function parameters of the patients.</p> <p>Conclusions</p> <p>Taken together, we show that, in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-β<sub>1</sub> in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD.</p>http://respiratory-research.com/content/13/1/116COPDInflammationFibrosisBDNFTGF-β<sub>1</sub> |
| spellingShingle | Stoll Paul Wuertemberger Urs Bratke Kai Zingler Christiana Virchow J Christian Lommatzsch Marek Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD Respiratory Research COPD Inflammation Fibrosis BDNF TGF-β<sub>1</sub> |
| title | Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD |
| title_full | Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD |
| title_fullStr | Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD |
| title_full_unstemmed | Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD |
| title_short | Stage-dependent association of BDNF and TGF-β<sub>1</sub> with lung function in stable COPD |
| title_sort | stage dependent association of bdnf and tgf β sub 1 sub with lung function in stable copd |
| topic | COPD Inflammation Fibrosis BDNF TGF-β<sub>1</sub> |
| url | http://respiratory-research.com/content/13/1/116 |
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