Radiolabeled Dendrimers for Nuclear Medicine Applications
Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclid...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/22/9/1350 |
| _version_ | 1817984120425283584 |
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| author | Lingzhou Zhao Meilin Zhu Yujie Li Yan Xing Jinhua Zhao |
| author_facet | Lingzhou Zhao Meilin Zhu Yujie Li Yan Xing Jinhua Zhao |
| author_sort | Lingzhou Zhao |
| collection | DOAJ |
| description | Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclides, dendrimers provide versatile platforms in this filed to build abundant multifunctional radiolabeled nanoparticles for nuclear medicine applications. This review gives special focus to recent advances in dendrimer-based nuclear medicine agents for the imaging and treatment of cancer, cardiovascular and other diseases. Radiolabeling strategies for different radionuclides and several challenges involved in clinical translation of radiolabeled dendrimers are extensively discussed. |
| first_indexed | 2024-04-13T23:41:31Z |
| format | Article |
| id | doaj.art-45776788db7c4c65870d00b10196d7be |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T23:41:31Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-45776788db7c4c65870d00b10196d7be2022-12-22T02:24:29ZengMDPI AGMolecules1420-30492017-08-01229135010.3390/molecules22091350molecules22091350Radiolabeled Dendrimers for Nuclear Medicine ApplicationsLingzhou Zhao0Meilin Zhu1Yujie Li2Yan Xing3Jinhua Zhao4Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaBasic Medical College, Ningxia Medical University, Yinchuan 750004, Ningxia, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaRecent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclides, dendrimers provide versatile platforms in this filed to build abundant multifunctional radiolabeled nanoparticles for nuclear medicine applications. This review gives special focus to recent advances in dendrimer-based nuclear medicine agents for the imaging and treatment of cancer, cardiovascular and other diseases. Radiolabeling strategies for different radionuclides and several challenges involved in clinical translation of radiolabeled dendrimers are extensively discussed.https://www.mdpi.com/1420-3049/22/9/1350dendrimersnuclear medicinePETSPECTradionuclide therapyradiolabeling |
| spellingShingle | Lingzhou Zhao Meilin Zhu Yujie Li Yan Xing Jinhua Zhao Radiolabeled Dendrimers for Nuclear Medicine Applications Molecules dendrimers nuclear medicine PET SPECT radionuclide therapy radiolabeling |
| title | Radiolabeled Dendrimers for Nuclear Medicine Applications |
| title_full | Radiolabeled Dendrimers for Nuclear Medicine Applications |
| title_fullStr | Radiolabeled Dendrimers for Nuclear Medicine Applications |
| title_full_unstemmed | Radiolabeled Dendrimers for Nuclear Medicine Applications |
| title_short | Radiolabeled Dendrimers for Nuclear Medicine Applications |
| title_sort | radiolabeled dendrimers for nuclear medicine applications |
| topic | dendrimers nuclear medicine PET SPECT radionuclide therapy radiolabeling |
| url | https://www.mdpi.com/1420-3049/22/9/1350 |
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