Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues.
Triple-negative breast cancer (TNBC) is one of the breast cancer subtype that displays a high risk of early recurrence and short overall survival. Improvement of the prognosis of patients with TNBC requires identifying a predictive factor of recurrence, which would make it possible to provide benefi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5568295?pdf=render |
| _version_ | 1819237980438528000 |
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| author | Yuko Hosokawa Noritaka Masaki Shiro Takei Makoto Horikawa Shoko Matsushita Eiji Sugiyama Hiroyuki Ogura Norihiko Shiiya Mitsutoshi Setou |
| author_facet | Yuko Hosokawa Noritaka Masaki Shiro Takei Makoto Horikawa Shoko Matsushita Eiji Sugiyama Hiroyuki Ogura Norihiko Shiiya Mitsutoshi Setou |
| author_sort | Yuko Hosokawa |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) is one of the breast cancer subtype that displays a high risk of early recurrence and short overall survival. Improvement of the prognosis of patients with TNBC requires identifying a predictive factor of recurrence, which would make it possible to provide beneficial personalized treatment. However, no clinically reliable predictive factor is currently known. In this study, we investigated the predictive factor of recurrence in TNBC using matrix-assisted laser desorption/ionization-imaging mass spectrometry for lipid profiling of breast cancer specimens obtained from three and six patients with recurrent and non-recurrent TNBC, respectively. The signal for phosphatidylcholine (PC) (32:1) at m/z 732.5 was significantly higher in the recurrence group compared to the non-recurrence group (P = 0.024). PC (32:1) was more abundant in the cancer epithelial area than it was in the surrounding stroma, suggesting that abnormal lipid metabolism was associated with malignant transformation. Our results indicate PC (32:1) as a candidate predictive factor of TNBC recurrence. A future prospective study investigating whether personalized therapy based on PC (32:1) intensity improves the prognosis of patients with TNBC is recommended. |
| first_indexed | 2024-12-23T13:28:57Z |
| format | Article |
| id | doaj.art-4577b1fda6644dc88e54819b49ffe2f9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T13:28:57Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4577b1fda6644dc88e54819b49ffe2f92022-12-21T17:45:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018372410.1371/journal.pone.0183724Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues.Yuko HosokawaNoritaka MasakiShiro TakeiMakoto HorikawaShoko MatsushitaEiji SugiyamaHiroyuki OguraNorihiko ShiiyaMitsutoshi SetouTriple-negative breast cancer (TNBC) is one of the breast cancer subtype that displays a high risk of early recurrence and short overall survival. Improvement of the prognosis of patients with TNBC requires identifying a predictive factor of recurrence, which would make it possible to provide beneficial personalized treatment. However, no clinically reliable predictive factor is currently known. In this study, we investigated the predictive factor of recurrence in TNBC using matrix-assisted laser desorption/ionization-imaging mass spectrometry for lipid profiling of breast cancer specimens obtained from three and six patients with recurrent and non-recurrent TNBC, respectively. The signal for phosphatidylcholine (PC) (32:1) at m/z 732.5 was significantly higher in the recurrence group compared to the non-recurrence group (P = 0.024). PC (32:1) was more abundant in the cancer epithelial area than it was in the surrounding stroma, suggesting that abnormal lipid metabolism was associated with malignant transformation. Our results indicate PC (32:1) as a candidate predictive factor of TNBC recurrence. A future prospective study investigating whether personalized therapy based on PC (32:1) intensity improves the prognosis of patients with TNBC is recommended.http://europepmc.org/articles/PMC5568295?pdf=render |
| spellingShingle | Yuko Hosokawa Noritaka Masaki Shiro Takei Makoto Horikawa Shoko Matsushita Eiji Sugiyama Hiroyuki Ogura Norihiko Shiiya Mitsutoshi Setou Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues. PLoS ONE |
| title | Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues. |
| title_full | Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues. |
| title_fullStr | Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues. |
| title_full_unstemmed | Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues. |
| title_short | Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues. |
| title_sort | recurrent triple negative breast cancer tnbc tissues contain a higher amount of phosphatidylcholine 32 1 than non recurrent tnbc tissues |
| url | http://europepmc.org/articles/PMC5568295?pdf=render |
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