Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa.
Facing the dual burden of invasive cervical cancer and HIV in sub-Saharan Africa, the identification of preventable determinants of Cervical Intraepithelial Neoplasia (CIN) in HIV-infected women is of paramount importance.A cervical cancer screening based on visual inspection methods was proposed to...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3942459?pdf=render |
| _version_ | 1818267020900171776 |
|---|---|
| author | Antoine Jaquet Apollinaire Horo Didier K Ekouevi Badian Toure Patrick A Coffie Benjamin Effi Severin Lenaud Eugene Messou Albert Minga Annie J Sasco François Dabis IeDEA West Africa Collaboration |
| author_facet | Antoine Jaquet Apollinaire Horo Didier K Ekouevi Badian Toure Patrick A Coffie Benjamin Effi Severin Lenaud Eugene Messou Albert Minga Annie J Sasco François Dabis IeDEA West Africa Collaboration |
| author_sort | Antoine Jaquet |
| collection | DOAJ |
| description | Facing the dual burden of invasive cervical cancer and HIV in sub-Saharan Africa, the identification of preventable determinants of Cervical Intraepithelial Neoplasia (CIN) in HIV-infected women is of paramount importance.A cervical cancer screening based on visual inspection methods was proposed to HIV-infected women in care in Abidjan, Côte d'Ivoire. Positively screened women were referred for a colposcopy to a gynaecologist who performed directed biopsies.Of the 2,998 HIV-infected women enrolled, 132 (4.4%) CIN of any grade (CIN+) were identified. Women had been followed-up for a median duration of three years [IQR: 1-5] and 76% were on antiretroviral treatment (ART). Their median most recent CD4 count was 452 [IQR: 301-621] cells/mm3. In multivariate analysis, CIN+ was associated with a most recent CD4 count >350 cells/mm3 (OR: 0.3; 95% CI: 0.2-0.6) or ≥200-350 cells/mm3 (OR 0.6; 95% CI 0.4-1.0) (Ref: <200 cells/mm3 CD4) (p<10-4).The presence of CIN+ is less common among HIV-infected women with limited or no immune deficiency. Despite the potential impact of immunological recovery on the reduction of premalignant cervical lesions through the use of ART, cervical cancer prevention, including screening and vaccination remains a priority in West Africa while ART is rolled-out. |
| first_indexed | 2024-12-12T20:15:58Z |
| format | Article |
| id | doaj.art-45789525032c45efbf4c973f32c28fbb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T20:15:58Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-45789525032c45efbf4c973f32c28fbb2022-12-22T00:13:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9062510.1371/journal.pone.0090625Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa.Antoine JaquetApollinaire HoroDidier K EkoueviBadian TourePatrick A CoffieBenjamin EffiSeverin LenaudEugene MessouAlbert MingaAnnie J SascoFrançois DabisIeDEA West Africa CollaborationFacing the dual burden of invasive cervical cancer and HIV in sub-Saharan Africa, the identification of preventable determinants of Cervical Intraepithelial Neoplasia (CIN) in HIV-infected women is of paramount importance.A cervical cancer screening based on visual inspection methods was proposed to HIV-infected women in care in Abidjan, Côte d'Ivoire. Positively screened women were referred for a colposcopy to a gynaecologist who performed directed biopsies.Of the 2,998 HIV-infected women enrolled, 132 (4.4%) CIN of any grade (CIN+) were identified. Women had been followed-up for a median duration of three years [IQR: 1-5] and 76% were on antiretroviral treatment (ART). Their median most recent CD4 count was 452 [IQR: 301-621] cells/mm3. In multivariate analysis, CIN+ was associated with a most recent CD4 count >350 cells/mm3 (OR: 0.3; 95% CI: 0.2-0.6) or ≥200-350 cells/mm3 (OR 0.6; 95% CI 0.4-1.0) (Ref: <200 cells/mm3 CD4) (p<10-4).The presence of CIN+ is less common among HIV-infected women with limited or no immune deficiency. Despite the potential impact of immunological recovery on the reduction of premalignant cervical lesions through the use of ART, cervical cancer prevention, including screening and vaccination remains a priority in West Africa while ART is rolled-out.http://europepmc.org/articles/PMC3942459?pdf=render |
| spellingShingle | Antoine Jaquet Apollinaire Horo Didier K Ekouevi Badian Toure Patrick A Coffie Benjamin Effi Severin Lenaud Eugene Messou Albert Minga Annie J Sasco François Dabis IeDEA West Africa Collaboration Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa. PLoS ONE |
| title | Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa. |
| title_full | Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa. |
| title_fullStr | Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa. |
| title_full_unstemmed | Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa. |
| title_short | Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa. |
| title_sort | risk factors for cervical intraepithelial neoplasia in hiv infected women on antiretroviral treatment in cote d ivoire west africa |
| url | http://europepmc.org/articles/PMC3942459?pdf=render |
| work_keys_str_mv | AT antoinejaquet riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT apollinairehoro riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT didierkekouevi riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT badiantoure riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT patrickacoffie riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT benjamineffi riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT severinlenaud riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT eugenemessou riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT albertminga riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT anniejsasco riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT francoisdabis riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica AT iedeawestafricacollaboration riskfactorsforcervicalintraepithelialneoplasiainhivinfectedwomenonantiretroviraltreatmentincotedivoirewestafrica |