Interplay between TRIM7 and antiviral immunity
TRIM7 has been demonstrated to have significant roles in promoting host defense against viral infections and regulating immune signaling pathways. As an E3 ubiquitin ligase, it catalyzes the ubiquitination of various substrates, including adaptor proteins (MAVS and STING) and transcription factors (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1256882/full |
| _version_ | 1827855392834584576 |
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| author | Yiyang Liu Yiyang Liu Yiyang Liu Lu Jiang Lu Jiang Xuemeng Sun Xuemeng Sun Yixuan Song Yixuan Song Yihan Liu Yihan Liu Leiliang Zhang Leiliang Zhang Leiliang Zhang |
| author_facet | Yiyang Liu Yiyang Liu Yiyang Liu Lu Jiang Lu Jiang Xuemeng Sun Xuemeng Sun Yixuan Song Yixuan Song Yihan Liu Yihan Liu Leiliang Zhang Leiliang Zhang Leiliang Zhang |
| author_sort | Yiyang Liu |
| collection | DOAJ |
| description | TRIM7 has been demonstrated to have significant roles in promoting host defense against viral infections and regulating immune signaling pathways. As an E3 ubiquitin ligase, it catalyzes the ubiquitination of various substrates, including adaptor proteins (MAVS and STING) and transcription factors (NF-κB and IRF3), thereby exerting positive or negative regulation on immune signal pathways. However, viruses have developed immune evasion mechanisms to counteract TRIM7. Some viruses can inhibit TRIM7 function by targeting it for degradation or sequestering it away from its targets. Moreover, TRIM7 may even facilitate viral infection by ubiquitinating viral proteins, including envelope proteins that are critical for tissue and species tropism. A comprehensive understanding of the interaction between TRIM7 and antiviral immunity is crucial for the development of innovative treatments for viral diseases. |
| first_indexed | 2024-03-12T11:49:31Z |
| format | Article |
| id | doaj.art-45799fd1844f48d88451e4a544e5883d |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-12T11:49:31Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-45799fd1844f48d88451e4a544e5883d2023-08-31T10:14:16ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-08-011310.3389/fcimb.2023.12568821256882Interplay between TRIM7 and antiviral immunityYiyang Liu0Yiyang Liu1Yiyang Liu2Lu Jiang3Lu Jiang4Xuemeng Sun5Xuemeng Sun6Yixuan Song7Yixuan Song8Yihan Liu9Yihan Liu10Leiliang Zhang11Leiliang Zhang12Leiliang Zhang13Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaTRIM7 has been demonstrated to have significant roles in promoting host defense against viral infections and regulating immune signaling pathways. As an E3 ubiquitin ligase, it catalyzes the ubiquitination of various substrates, including adaptor proteins (MAVS and STING) and transcription factors (NF-κB and IRF3), thereby exerting positive or negative regulation on immune signal pathways. However, viruses have developed immune evasion mechanisms to counteract TRIM7. Some viruses can inhibit TRIM7 function by targeting it for degradation or sequestering it away from its targets. Moreover, TRIM7 may even facilitate viral infection by ubiquitinating viral proteins, including envelope proteins that are critical for tissue and species tropism. A comprehensive understanding of the interaction between TRIM7 and antiviral immunity is crucial for the development of innovative treatments for viral diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1256882/fullTRIM7E3 ubiquitin ligaseMAVSSTINGenterovirus |
| spellingShingle | Yiyang Liu Yiyang Liu Yiyang Liu Lu Jiang Lu Jiang Xuemeng Sun Xuemeng Sun Yixuan Song Yixuan Song Yihan Liu Yihan Liu Leiliang Zhang Leiliang Zhang Leiliang Zhang Interplay between TRIM7 and antiviral immunity Frontiers in Cellular and Infection Microbiology TRIM7 E3 ubiquitin ligase MAVS STING enterovirus |
| title | Interplay between TRIM7 and antiviral immunity |
| title_full | Interplay between TRIM7 and antiviral immunity |
| title_fullStr | Interplay between TRIM7 and antiviral immunity |
| title_full_unstemmed | Interplay between TRIM7 and antiviral immunity |
| title_short | Interplay between TRIM7 and antiviral immunity |
| title_sort | interplay between trim7 and antiviral immunity |
| topic | TRIM7 E3 ubiquitin ligase MAVS STING enterovirus |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1256882/full |
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